DOI: 10.1126/science.1411538. Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

10.1126/science.1411538

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Described here are neural networks capable of predicting a drug's mechanism of action from its pattern of activity against a panel of 60 malignant cell lines in the National Cancer Institute's drug screening program. Given six possible classes of mechanism, the network misses the correct category for only 12 out of 141 agents (8.5 percent), whereas linear discriminant analysis, a standard statistical technique, misses 20 out of 141 (14.2 percent). The success of the neural net indicates several things. (i) The cell line response patterns are rich in information about mechanism. (ii) Appropriately designed neural networks can make effective use of that information. (iii) Trained networks can be used to classify prospectively the more than 10,000 agents per year tested by the screening program. Related networks, in combination with classical statistical tools, will help in a variety of ways to move new anticancer agents through the pipeline from in vitro studies to clinical application.

Bibliography

Weinstein, J. N., Kohn, K. W., Grever, M. R., Viswanadhan, V. N., Rubinstein, L. V., Monks, A. P., Scudiero, D. A., Welch, L., Koutsoukos, A. D., Chiausa, A. J., & Paull, K. D. (1992). Neural Computing in Cancer Drug Development: Predicting Mechanism of Action. Science, 258(5081), 447â451.

Authors 11

John N. Weinstein (first)
Kurt W. Kohn (additional)
Michael R. Grever (additional)
Vellarkad N. Viswanadhan (additional)
Lawrence V. Rubinstein (additional)
Anne P. Monks (additional)
Dominic A. Scudiero (additional)
Lester Welch (additional)
Antonis D. Koutsoukos (additional)
August J. Chiausa (additional)
Kenneth D. Paull (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:53 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 1:19 a.m.)
Issued	32 years, 10 months ago (Oct. 16, 1992)
Published	32 years, 10 months ago (Oct. 16, 1992)
Published Print	32 years, 10 months ago (Oct. 16, 1992)

Funders 0

None

BibTeX

@article{Weinstein_1992, title={Neural Computing in Cancer Drug Development: Predicting Mechanism of Action}, volume={258}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1411538}, DOI={10.1126/science.1411538}, number={5081}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Weinstein, John N. and Kohn, Kurt W. and Grever, Michael R. and Viswanadhan, Vellarkad N. and Rubinstein, Lawrence V. and Monks, Anne P. and Scudiero, Dominic A. and Welch, Lester and Koutsoukos, Antonis D. and Chiausa, August J. and Paull, Kenneth D.}, year={1992}, month=oct, pages={447–451} }

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