DOI: 10.1126/science.1384129. Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin

Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin

10.1126/science.1384129

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Migration of human polymorphonuclear neutrophils on vitronectin is dependent on repeated transient increases in the concentration of intracellular free calcium ([Ca 2+ ] i ). A specific peptide inhibitor of the Ca 2+ -calmodulin-dependent phosphatase calcineurin was introduced into the cytoplasm of neutrophils. The peptide inhibited neutrophil migration on vitronectin by interfering with the release of the cells from sites of attachment. A similar reduction in motility on vitronectin occurred when cells were treated with the immunosuppressant FK506, which also inhibits calcineurin when bound to its binding protein, FKBP. These results indicate that a rise in [Ca 2+ ] i reduces integrin-mediated adhesion to vitronectin by a mechanism that requires calcineurin activity.

Bibliography

Hendey, B., Klee, C. B., & Maxfield, F. R. (1992). Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin. Science, 258(5080), 296â299.

Authors 3

Bill Hendey (first)
Claude B. Klee (additional)
Frederick R. Maxfield (additional)

References 29 Referenced 147

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 10:21 p.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:13 a.m.)
Issued	32 years, 10 months ago (Oct. 9, 1992)
Published	32 years, 10 months ago (Oct. 9, 1992)
Published Print	32 years, 10 months ago (Oct. 9, 1992)

Funders 0

None

BibTeX

@article{Hendey_1992, title={Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin}, volume={258}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1384129}, DOI={10.1126/science.1384129}, number={5080}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hendey, Bill and Klee, Claude B. and Maxfield, Frederick R.}, year={1992}, month=oct, pages={296–299} }

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