DOI: 10.1126/science.138.3545.1104. Hippocampal Ablation and Passive Avoidance

Hippocampal Ablation and Passive Avoidance

10.1126/science.138.3545.1104

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Six rats with bilateral ablation of the hippocampus and six rats with extensive destruction of the neocortex were trained to enter a small compartment, while hungry, for a food reward. After 35 trials, spread over 4 days of training, the animals were given a shock while they were eating in the goal box. After the shock the rats with cortical lesions would not enter the goal compartment on the remainder of the trials given on the same day and only gradually began to re-enter over the next 2 days. The effect of the shock on the subjects with hippocampal ablation was slight and transient, suggesting that the ability to make passive avoidance responses was impaired.

Bibliography

Isaacson, R. L., & Wickelgren, W. O. (1962). Hippocampal Ablation and Passive Avoidance. Science, 138(3545), 1104â1106.

Authors 2

Robert L. Isaacson (first)
Warren O. Wickelgren (additional)

References 4 Referenced 133

ISAACSON, R.L., EFFECT OF RADICAL HIPPOCAMPAL ABLATION ON ACQUISITION OF AVOIDANCE RESPONSE, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 54: 625 (1961). (10.1037/h0047286) / JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY (1961)
KAADA, B.R., IMPAIRED ACQUISITION OF PASSIVE AVOIDANCE BEHAVIOR BY SUBCALLOSAL, SEPTAL, HYPOTHALAMIC, AND INSULAR LESIONS IN RATS, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 55: 661 (1962). (10.1037/h0044756) / JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY (1962)
KIMURA, D, EFFECTS OF SELECTIVE HIPPOCAMPAL DAMAGE ON AVOIDANCE-BEHAVIOR IN THE RAT, CANADIAN JOURNAL OF PSYCHOLOGY 12: 213 (1958). (10.1037/h0083740) / CANADIAN JOURNAL OF PSYCHOLOGY (1958)
MCCLEARY, R.A., RESPONSE SPECIFICITY IN BEHAVIORAL EFFECTS OF LIMBIC SYSTEM LESIONS IN CAT, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 54: 605 (1961). (10.1037/h0044019) / JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY (1961)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:58 a.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 10:51 p.m.)
Indexed	1 month, 1 week ago (July 20, 2025, 12:03 a.m.)
Issued	62 years, 8 months ago (Dec. 7, 1962)
Published	62 years, 8 months ago (Dec. 7, 1962)
Published Print	62 years, 8 months ago (Dec. 7, 1962)

Funders 0

None

BibTeX

@article{Isaacson_1962, title={Hippocampal Ablation and Passive Avoidance}, volume={138}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.138.3545.1104}, DOI={10.1126/science.138.3545.1104}, number={3545}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Isaacson, Robert L. and Wickelgren, Warren O.}, year={1962}, month=dec, pages={1104–1106} }

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