DOI: 10.1126/science.1378648. Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

10.1126/science.1378648

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

As a first step in a program to use genetically altered mice in the study of memory mechanisms, mutant mice were produced that do not express the α-calcium-calmodulin-dependent kinase II (α-CaMKII). The α-CaMKII is highly enriched in postsynaptic densities of hippocampus and neocortex and may be involved in the regulation of long-term potentiation (LTP). Such mutant mice exhibited mostly normal behaviors and presented no obvious neuroanatomical defects. Whole cell recordings reveal that postsynaptic mechanisms, including N -methyl-D-aspartate (NMDA) receptor function, are intact. Despite normal postsynaptic mechanisms, these mice are deficient in their ability to produce LTP and are therefore a suitable model for studying the relation between LTP and learning processes.

Bibliography

Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992). Deficient Hippocampal Long-Term Potentiation in Î±-Calcium-Calmodulin Kinase II Mutant Mice. Science, 257(5067), 201â206.

Authors 4

Alcino J. Silva (first)
Charles F. Stevens (additional)
Susumu Tonegawa (additional)
Yanyan Wang (additional)

References 29 Referenced 1,209

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10.1038/346724a0
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BURGIN, K.E., INSITU HYBRIDIZATION HISTOCHEMISTRY OF CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE IN DEVELOPING RAT-BRAIN, JOURNAL OF NEUROSCIENCE 10: 1788 (1990). (10.1523/JNEUROSCI.10-06-01788.1990) / JOURNAL OF NEUROSCIENCE (1990)
10.1126/science.2660260
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COLBRAN, R.J., CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE-II, BIOCHEMICAL JOURNAL 258: 313 (1989). (10.1042/bj2580313) / BIOCHEMICAL JOURNAL (1989)
DAVIS, M, THE ROLE OF THE AMYGDALA IN FEAR-POTENTIATED STARTLE - IMPLICATIONS FOR ANIMAL-MODELS OF ANXIETY, TRENDS IN PHARMACOLOGICAL SCIENCES 13: 35 (1992). (10.1016/0165-6147(92)90014-W) / TRENDS IN PHARMACOLOGICAL SCIENCES (1992)
DOUGLAS, R.J., HIPPOCAMPUS AND BEHAVIOR, PSYCHOLOGICAL BULLETIN 67: 416 (1967). (10.1037/h0024599) / PSYCHOLOGICAL BULLETIN (1967)
ERONDU, N.E., REGIONAL DISTRIBUTION OF TYPE-II CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE IN RAT-BRAIN, JOURNAL OF NEUROSCIENCE 5: 3270 (1985). (10.1523/JNEUROSCI.05-12-03270.1985) / JOURNAL OF NEUROSCIENCE (1985)
FALLS, W.A., EXTINCTION OF FEAR-POTENTIATED STARTLE - BLOCKADE BY INFUSION OF AN NMDA ANTAGONIST INTO THE AMYGDALA, JOURNAL OF NEUROSCIENCE 12: 854 (1992). (10.1523/JNEUROSCI.12-03-00854.1992) / JOURNAL OF NEUROSCIENCE (1992)
10.1038/354076a0
HANSON, P.I., EXPRESSION OF A MULTIFUNCTIONAL CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE AND MUTATIONAL ANALYSIS OF ITS AUTO-REGULATION, NEURON 3: 59 (1989). (10.1016/0896-6273(89)90115-3) / NEURON (1989)
JAHR, C.E., A QUANTITATIVE DESCRIPTION OF NMDA RECEPTOR-CHANNEL KINETIC-BEHAVIOR, JOURNAL OF NEUROSCIENCE 10: 1830 (1990). (10.1523/JNEUROSCI.10-06-01830.1990) / JOURNAL OF NEUROSCIENCE (1990)
JAHR, C.E., VOLTAGE DEPENDENCE OF NMDA-ACTIVATED MACROSCOPIC CONDUCTANCES PREDICTED BY SINGLE-CHANNEL KINETICS, JOURNAL OF NEUROSCIENCE 10: 3178 (1990). (10.1523/JNEUROSCI.10-09-03178.1990) / JOURNAL OF NEUROSCIENCE (1990)
LIN, J.W., EFFECTS OF SYNAPSIN-I AND CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE-II ON SPONTANEOUS NEUROTRANSMITTER RELEASE IN THE SQUID GIANT SYNAPSE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 8257 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
LISMAN, J.E., FEASIBILITY OF LONG-TERM STORAGE OF GRADED INFORMATION BY THE CA-2+/CALMODULIN-DEPENDENT PROTEIN-KINASE MOLECULES OF THE POSTSYNAPTIC DENSITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5320 (1988). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1988)
MALENKA, R.C., AN ESSENTIAL ROLE FOR POSTSYNAPTIC CALMODULIN AND PROTEIN-KINASE ACTIVITY IN LONG-TERM POTENTIATION, NATURE 340: 554 (1989). (10.1038/340554a0) / NATURE (1989)
MALINOW, R, PRESYNAPTIC ENHANCEMENT SHOWN BY WHOLE-CELL RECORDINGS OF LONG-TERM POTENTIATION IN HIPPOCAMPAL SLICES, NATURE 346: 177 (1990). (10.1038/346177a0) / NATURE (1990)
10.1126/science.2549638
McGuinness, T. L., Journal of Biological Chemistry 260: 1696 (1985). (10.1016/S0021-9258(18)89650-8) / Journal of Biological Chemistry (1985)
MILLER, S.G., REGULATION OF BRAIN TYPE-II CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE BY AUTOPHOSPHORYLATION - A CA-2+-TRIGGERED MOLECULAR SWITCH, CELL 44: 861 (1986). (10.1016/0092-8674(86)90008-5) / CELL (1986)
MILLER, S.G., SEQUENCES OF AUTOPHOSPHORYLATION SITES IN NEURONAL TYPE-II CAM KINASE THAT CONTROL CA-2+-INDEPENDENT ACTIVITY, NEURON 1: 593 (1988). (10.1016/0896-6273(88)90109-2) / NEURON (1988)
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10.1038/354073a0
SCHULMAN, H, MULTIFUNCTIONAL CA-2+/CALMODULIN-DEPENDENT PROTEIN-KINASE - DOMAIN-STRUCTURE AND REGULATION, TRENDS IN BIOCHEMICAL SCIENCES 14: 62 (1989). (10.1016/0968-0004(89)90045-5) / TRENDS IN BIOCHEMICAL SCIENCES (1989)
10.1126/science.1321493
SILVA A.J. unpublished data.
THOMPSON, S, GERM LINE TRANSMISSION AND EXPRESSION OF A CORRECTED HPRT GENE PRODUCED BY GENE TARGETING IN EMBRYONIC STEM-CELLS, CELL 56: 313 (1989). (10.1016/0092-8674(89)90905-7) / CELL (1989)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 4:53 p.m.)
Indexed	3 days, 21 hours ago (Aug. 24, 2025, 6:52 p.m.)
Issued	33 years, 1 month ago (July 10, 1992)
Published	33 years, 1 month ago (July 10, 1992)
Published Print	33 years, 1 month ago (July 10, 1992)

Funders 0

None

BibTeX

@article{Silva_1992, title={Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice}, volume={257}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1378648}, DOI={10.1126/science.1378648}, number={5067}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Silva, Alcino J. and Stevens, Charles F. and Tonegawa, Susumu and Wang, Yanyan}, year={1992}, month=jul, pages={201–206} }

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