DOI: 10.1126/science.1352913. Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 <sup>+</sup> T Cells

Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells

10.1126/science.1352913

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The paucity of virus-laden CD4 + cells in individuals infected with human immunodeficiency virus type-1 (HIV-1) contrasts with the greatly reduced numbers and function of these lymphocytes. A pathway is described whereby dendritic cells carry HIV-1 to uninfected T cells, amplifying the cytopathic effects of small amounts of virus. After exposure to HIV-1, dendritic cells continue to present superantigens and antigens, forming clusters with T cells that are driven to replicate. Infection of the dendritic cells cannot be detected, but the clustered T cells form syncytia, release virions, and die. Carriage of HIV-1 by dendritic cells may facilitate the lysis and loss of antigen specific CD4 + T cells in acquired immunodeficiency syndrome.

Bibliography

Cameron, P. U., Freudenthal, P. S., Barker, J. M., Gezelter, S., Inaba, K., & Steinman, R. M. (1992). Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells. Science, 257(5068), 383â387.

Authors 6

Paul U. Cameron (first)
Peter S. Freudenthal (additional)
Jeanne M. Barker (additional)
Stuart Gezelter (additional)
Kayo Inaba (additional)
Ralph M. Steinman (additional)

References 34 Referenced 519

ADACHI, A, PRODUCTION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED RETROVIRUS IN HUMAN AND NONHUMAN CELLS TRANSFECTED WITH AN INFECTIOUS MOLECULAR CLONE, JOURNAL OF VIROLOGY 59: 284 (1986). (10.1128/jvi.59.2.284-291.1986) / JOURNAL OF VIROLOGY (1986)
ARMSTRONG, J.A., FOLLICULAR DENDRITIC CELLS AND VIRUS-LIKE PARTICLES IN AIDS-RELATED LYMPHADENOPATHY, LANCET 2: 370 (1984). / LANCET (1984)
BHARDWAJ, N, DENDRITIC CELLS ARE POTENT ANTIGEN-PRESENTING CELLS FOR MICROBIAL SUPERANTIGENS, JOURNAL OF EXPERIMENTAL MEDICINE 175: 267 (1992). (10.1084/jem.175.1.267) / JOURNAL OF EXPERIMENTAL MEDICINE (1992)
BIBERFELD, P, HTLV-III EXPRESSION IN INFECTED LYMPH-NODES AND RELEVANCE TO PATHOGENESIS OF LYMPHADENOPATHY, AMERICAN JOURNAL OF PATHOLOGY 125: 436 (1986). / AMERICAN JOURNAL OF PATHOLOGY (1986)
CAMERON, P.U., WESTERN-BLOT PROFILES, LYMPH-NODE ULTRASTRUCTURE AND VIRAL EXPRESSION IN HIV-INFECTED PATIENTS - A CORRELATIVE STUDY, CLINICAL AND EXPERIMENTAL IMMUNOLOGY 68: 465 (1987). / CLINICAL AND EXPERIMENTAL IMMUNOLOGY (1987)
CAMERON, P.U., DURING HIV-1 INFECTION MOST BLOOD DENDRITIC CELLS ARE NOT PRODUCTIVELY INFECTED AND CAN INDUCE ALLOGENEIC CD4+ T-CELLS CLONAL EXPANSION, CLINICAL AND EXPERIMENTAL IMMUNOLOGY 88: 226 (1992). / CLINICAL AND EXPERIMENTAL IMMUNOLOGY (1992)
10.1126/science.3277274
FLECHNER, E, ANTIGEN-SPECIFIC LYMPHOCYTES-T EFFICIENTLY CLUSTER WITH DENDRITIC CELLS IN THE HUMAN PRIMARY MIXED-LEUKOCYTE REACTION, CELLULAR IMMUNOLOGY 111: 183 (1988). (10.1016/0008-8749(88)90062-7) / CELLULAR IMMUNOLOGY (1988)
FREUDENTHAL, P.S., THE DISTINCT SURFACE OF HUMAN BLOOD DENDRITIC CELLS, AS OBSERVED AFTER AN IMPROVED ISOLATION METHOD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 7698 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
GOFF, S, ISOLATION AND PROPERTIES OF MOLONEY MURINE LEUKEMIA-VIRUS MUTANTS - USE OF A RAPID ASSAY FOR RELEASE OF VIRION REVERSE-TRANSCRIPTASE, JOURNAL OF VIROLOGY 38: 239 (1981). (10.1128/jvi.38.1.239-248.1981) / JOURNAL OF VIROLOGY (1981)
HARPER, M.E., DETECTION OF LYMPHOCYTES EXPRESSING HUMAN LYMPHOTROPIC-T VIRUS TYPE-III IN LYMPH-NODES AND PERIPHERAL-BLOOD FROM INFECTED INDIVIDUALS BY INSITU HYBRIDIZATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 772 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
INABA, K, RESTING AND SENSITIZED LYMPHOCYTES-T EXHIBIT DISTINCT STIMULATORY (ANTIGEN-PRESENTING CELL) REQUIREMENTS FOR GROWTH AND LYMPHOKINE RELEASE, JOURNAL OF EXPERIMENTAL MEDICINE 160: 1717 (1984). (10.1084/jem.160.6.1717) / JOURNAL OF EXPERIMENTAL MEDICINE (1984)
INABA, K, DIRECT ACTIVATION OF CD8+ CYTOTOXIC LYMPHOCYTE-T BY DENDRITIC CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 166: 182 (1987). (10.1084/jem.166.1.182) / JOURNAL OF EXPERIMENTAL MEDICINE (1987)
10.1126/science.6328660
LANGHOFF, E, CLONAL EXPANSION OF HUMAN LYMPHOCYTES-T INITIATED BY DENDRITIC CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 169: 315 (1989). (10.1084/jem.169.1.315) / JOURNAL OF EXPERIMENTAL MEDICINE (1989)
LANGHOFF, E, REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN PRIMARY DENDRITIC CELL-CULTURES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 7998 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
10.1038/333519a0
LIFSON, J.D., INDUCTION OF CD4-DEPENDENT CELL-FUSION BY THE HTLV-III/LAV ENVELOPE GLYCOPROTEIN, NATURE 323: 725 (1986). (10.1038/323725a0) / NATURE (1986)
10.1126/science.3010463
MACATONIA, S.E., SUPPRESSION OF IMMUNE-RESPONSES BY DENDRITIC CELLS INFECTED WITH HIV, IMMUNOLOGY 67: 285 (1989). / IMMUNOLOGY (1989)
MADDON, P.J., THE T4 GENE ENCODES THE AIDS VIRUS RECEPTOR AND IS EXPRESSED IN THE IMMUNE-SYSTEM AND THE BRAIN, CELL 47: 333 (1986). (10.1016/0092-8674(86)90590-8) / CELL (1986)
10.1126/science.2185544
MCDOUGAL, J.S., CELLULAR TROPISM OF THE HUMAN RETROVIRUS HTLV-III/LAV .1. ROLE OF T-CELL ACTIVATION AND EXPRESSION OF THE T4 ANTIGEN, JOURNAL OF IMMUNOLOGY 135: 3151 (1985). (10.4049/jimmunol.135.5.3151) / JOURNAL OF IMMUNOLOGY (1985)
MCELRATH, M.J., LATENT HIV-1 INFECTION IN ENRICHED POPULATIONS OF BLOOD MONOCYTES AND T-CELLS FROM SEROPOSITIVE PATIENTS, JOURNAL OF CLINICAL INVESTIGATION 87: 27 (1991). (10.1172/JCI114981) / JOURNAL OF CLINICAL INVESTIGATION (1991)
OU, C.Y., DNA AMPLIFICATION FOR DIRECT DETECTION OF HIV-1 IN DNA OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS, SCIENCE 239: 295 (1988). (10.1126/science.3336784) / SCIENCE (1988)
PANG, S, HIGH-LEVELS OF UNINTEGRATED HIV-1 DNA IN BRAIN-TISSUE OF AIDS DEMENTIA PATIENTS, NATURE 343: 85 (1990). (10.1038/343085a0) / NATURE (1990)
PATTERSON, S, MORPHOLOGY AND PHENOTYPE OF DENDRITIC CELLS FROM PERIPHERAL-BLOOD AND THEIR PRODUCTIVE AND NONPRODUCTIVE INFECTION WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, IMMUNOLOGY 72: 361 (1991). / IMMUNOLOGY (1991)
PATTERSON, S, SUSCEPTIBILITY OF HUMAN PERIPHERAL-BLOOD DENDRITIC CELLS TO INFECTION BY HUMAN-IMMUNODEFICIENCY-VIRUS, JOURNAL OF GENERAL VIROLOGY 68: 1177 (1987). (10.1099/0022-1317-68-4-1177) / JOURNAL OF GENERAL VIROLOGY (1987)
10.1126/science.3461561
10.1126/science.2665081
STEINMAN, R.M., THE DENDRITIC CELL SYSTEM AND ITS ROLE IN IMMUNOGENICITY, ANNUAL REVIEW OF IMMUNOLOGY 9: 271 (1991). (10.1146/annurev.iy.09.040191.001415) / ANNUAL REVIEW OF IMMUNOLOGY (1991)
TENNERRACZ, K, CELL-FREE HIV IN LYMPH-NODES OF PATIENTS WITH AIDS AND GENERALIZED LYMPHADENOPATHY, NEW ENGLAND JOURNAL OF MEDICINE 318: 49 (1988). (10.1056/NEJM198801073180113) / NEW ENGLAND JOURNAL OF MEDICINE (1988)
WILLEY, R.L., INVITRO MUTAGENESIS IDENTIFIES A REGION WITHIN THE ENVELOPE GENE OF THE HUMAN IMMUNODEFICIENCY VIRUS THAT IS CRITICAL FOR INFECTIVITY, JOURNAL OF VIROLOGY 62: 139 (1988). (10.1128/jvi.62.1.139-147.1988) / JOURNAL OF VIROLOGY (1988)
ZACK, J.A., HIV-1 ENTRY INTO QUIESCENT PRIMARY LYMPHOCYTES - MOLECULAR ANALYSIS REVEALS A LABILE, LATENT VIRAL STRUCTURE, CELL 61: 213 (1990). (10.1016/0092-8674(90)90802-L) / CELL (1990)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 4:07 p.m.)
Indexed	1 month, 1 week ago (July 16, 2025, 8:36 a.m.)
Issued	33 years, 1 month ago (July 17, 1992)
Published	33 years, 1 month ago (July 17, 1992)
Published Print	33 years, 1 month ago (July 17, 1992)

Funders 0

None

BibTeX

@article{Cameron_1992, title={Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells}, volume={257}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1352913}, DOI={10.1126/science.1352913}, number={5068}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cameron, Paul U. and Freudenthal, Peter S. and Barker, Jeanne M. and Gezelter, Stuart and Inaba, Kayo and Steinman, Ralph M.}, year={1992}, month=jul, pages={383–387} }

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