DOI: 10.1126/science.1261197. A molecular census of 26 <i>S</i> proteasomes in intact neurons

A molecular census of 26 S proteasomes in intact neurons

10.1126/science.1261197

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A detailed look at proteasomes in situ The 26 S proteasome is a protein machine that degrades intracellular proteins in the cytosol. The proteasome is critical for protein quality control and for the regulation of numerous cellular processes in eukaryotic cells. The structure of isolated proteasomes is well established, but how intact proteasomes look within the cell is less clear. Asano et al. used an improved approach to electron cryotomography to look at proteasomes in intact hippocampal neurons. Their analysis suggests that these cells only use about 20% of their proteasomes in an unstressed state, which leaves significant spare capacity to deal with proteotoxic stress. Science , this issue p. 439

Bibliography

Asano, S., Fukuda, Y., Beck, F., Aufderheide, A., FÃ¶rster, F., Danev, R., & Baumeister, W. (2015). A molecular census of 26 S proteasomes in intact neurons. Science, 347(6220), 439â442.

Authors 7

Shoh Asano (first)
Yoshiyuki Fukuda (additional)
Florian Beck (additional)
Antje Aufderheide (additional)
Friedrich Förster (additional)
Radostin Danev (additional)
Wolfgang Baumeister (additional)

References 41 Referenced 289

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Dates

Type	When
Created	10 years, 6 months ago (Jan. 22, 2015, 2:04 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 3:52 p.m.)
Indexed	2 weeks ago (Aug. 6, 2025, 8:36 a.m.)
Issued	10 years, 6 months ago (Jan. 23, 2015)
Published	10 years, 6 months ago (Jan. 23, 2015)
Published Print	10 years, 6 months ago (Jan. 23, 2015)

Funders 1

European Commission under FP7 10.13039/100011102 Seventh Framework Programme
Region: Europe
gov (National government)
Labels13
1. EC Seventh Framework Programm
2. European Commission Seventh Framework Programme
3. EU Seventh Framework Programme
4. European Union Seventh Framework Programme
5. EU 7th Framework Programme
6. European Union 7th Framework Programme
7. Siebten Rahmenprogramm
8. Séptimo Programa Marco
9. Septième programme-cadre
10. Settimo programma quadro
11. 7th Framework Programme
12. Seventh EU Framework Programme
13. FP7
Awards1
1. ERC-2012-SyG_318987-ToPAG

BibTeX

@article{Asano_2015, title={A molecular census of 26 S proteasomes in intact neurons}, volume={347}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1261197}, DOI={10.1126/science.1261197}, number={6220}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Asano, Shoh and Fukuda, Yoshiyuki and Beck, Florian and Aufderheide, Antje and Förster, Friedrich and Danev, Radostin and Baumeister, Wolfgang}, year={2015}, month=jan, pages={439–442} }

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