DOI: 10.1126/science.1260825. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

10.1126/science.1260825

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Crunching the numbers to explain cancer Why do some tissues give rise to cancer in humans a million times more frequently than others? Tomasetti and Vogelstein conclude that these differences can be explained by the number of stem cell divisions. By plotting the lifetime incidence of various cancers against the estimated number of normal stem cell divisions in the corresponding tissues over a lifetime, they found a strong correlation extending over five orders of magnitude. This suggests that random errors occurring during DNA replication in normal stem cells are a major contributing factor in cancer development. Remarkably, this “bad luck” component explains a far greater number of cancers than do hereditary and environmental factors. Science , this issue p. 78

Bibliography

Tomasetti, C., & Vogelstein, B. (2015). Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science, 347(6217), 78â81.

Authors 2

Cristian Tomasetti (first)
Bert Vogelstein (additional)

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Dates

Type	When
Created	10 years, 7 months ago (Jan. 1, 2015, 2:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 3:51 p.m.)
Indexed	11 minutes ago (Aug. 26, 2025, 1:13 a.m.)
Issued	10 years, 7 months ago (Jan. 2, 2015)
Published	10 years, 7 months ago (Jan. 2, 2015)
Published Print	10 years, 7 months ago (Jan. 2, 2015)

Funders 4

NIH 10.13039/100000002 National Institutes of Health
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards4
1. R37-CA43460
2. RO1-CA57345
3. P50-CA62924
4. P30-CA006973
The Virginia and D. K. Ludwig Fund for Cancer Research
The Lustgarten Foundation for Pancreatic Cancer Research
The Sol Goldman Center for Pancreatic Cancer Research

BibTeX

@article{Tomasetti_2015, title={Variation in cancer risk among tissues can be explained by the number of stem cell divisions}, volume={347}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1260825}, DOI={10.1126/science.1260825}, number={6217}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Tomasetti, Cristian and Vogelstein, Bert}, year={2015}, month=jan, pages={78–81} }

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