DOI: 10.1126/science.1257452. Computational design of water-soluble α-helical barrels

Computational design of water-soluble α-helical barrels

10.1126/science.1257452

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Building with alphahelical coiled coils Understanding how proteins fold into well-defined three-dimensional structures has been a longstanding challenge. Increased understanding has led to increased success at designing proteins that mimic existing protein folds. This raises the possibility of custom design of proteins with structures not seen in nature. Thomson et al. describe the design of channelcontaining α-helical barrels, and Huang et al. designed hyperstable helical bundles. Both groups used rational and computational design to make new protein structures based on α-helical coiled coils but took different routes to reach different target structures. Science , this issue p. 485 , p. 481

Bibliography

Thomson, A. R., Wood, C. W., Burton, A. J., Bartlett, G. J., Sessions, R. B., Brady, R. L., & Woolfson, D. N. (2014). Computational design of water-soluble Î±-helical barrels. Science, 346(6208), 485â488.

Authors 7

Andrew R. Thomson (first)
Christopher W. Wood (additional)
Antony J. Burton (additional)
Gail J. Bartlett (additional)
Richard B. Sessions (additional)
R. Leo Brady (additional)
Derek N. Woolfson (additional)

References 41 Referenced 331

Dates

Type	When
Created	10 years, 10 months ago (Oct. 23, 2014, 5:07 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 2:57 p.m.)
Indexed	2 months, 1 week ago (June 17, 2025, 5:08 a.m.)
Issued	10 years, 10 months ago (Oct. 24, 2014)
Published	10 years, 10 months ago (Oct. 24, 2014)
Published Print	10 years, 10 months ago (Oct. 24, 2014)

Funders 0

None

BibTeX

@article{Thomson_2014, title={Computational design of water-soluble α-helical barrels}, volume={346}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1257452}, DOI={10.1126/science.1257452}, number={6208}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Thomson, Andrew R. and Wood, Christopher W. and Burton, Antony J. and Bartlett, Gail J. and Sessions, Richard B. and Brady, R. Leo and Woolfson, Derek N.}, year={2014}, month=oct, pages={485–488} }

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