DOI: 10.1126/science.1255030. How the ribosome hands the A-site tRNA to the P site during EF-G

How the ribosome hands the A-site tRNA to the P site during EF-G–catalyzed translocation

10.1126/science.1255030

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Caught in the act of making protein The ribosome is a large RNA-protein complex that converts the genetic code stored in messenger RNA (mRNA) into proteins. Zhou et al. have determined the structure of a bacterial ribosome caught in the act of decoding an mRNA. Transfer RNAs (tRNAs) decipher the genetic code in the mRNA to ensure that the ribosome uses the correct amino acids. The structure shows tRNAs in the process of being moved between successive protein-building binding pockets as the ribosome reads the mRNA like a piece of old-fashion computer tape. Science , this issue p. 1188

Bibliography

Zhou, J., Lancaster, L., Donohue, J. P., & Noller, H. F. (2014). How the ribosome hands the A-site tRNA to the P site during EF-Gâcatalyzed translocation. Science, 345(6201), 1188â1191.

Authors 4

Jie Zhou (first)
Laura Lancaster (additional)
John Paul Donohue (additional)
Harry F. Noller (additional)

References 49 Referenced 157

Dates

Type	When
Created	10 years, 11 months ago (Sept. 4, 2014, 10:08 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 4:27 p.m.)
Indexed	1 month ago (July 26, 2025, 5:13 a.m.)
Issued	10 years, 11 months ago (Sept. 5, 2014)
Published	10 years, 11 months ago (Sept. 5, 2014)
Published Print	10 years, 11 months ago (Sept. 5, 2014)

Funders 0

None

BibTeX

@article{Zhou_2014, title={How the ribosome hands the A-site tRNA to the P site during EF-G–catalyzed translocation}, volume={345}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1255030}, DOI={10.1126/science.1255030}, number={6201}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Zhou, Jie and Lancaster, Laura and Donohue, John Paul and Noller, Harry F.}, year={2014}, month=sep, pages={1188–1191} }

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