Structure of the Yeast Mitochondrial Large Ribosomal Subunit
10.1126/science.1249410
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Mitoribosomes Mitochondria—found in all eukaryotic cells—have transferred most of their genes to the nuclear genome. The nuclear-localized mitochondrial genes are expressed and translated in the cytoplasm and the resulting mitochondrial proteins are imported into the mitochondria. Nevertheless, a few genes remain within mitochondria in the mitochondrial genome, and these genes are translated by mitochondrial ribosomes (mitoribosomes). Amunts et al. (p. 1485 ; see the Perspective by Kühlbrandt ) determined the structure of mitoribosomes from yeast using single-particle cryo–electron microscopy. The mitoribosome is highly diverged from the bacterial and eukaryotic ribosomes with, for example, a distinctive exit tunnel for the newly synthesized peptide, and a membrane facing protuberance that might help to anchor the mitoribosome to the mitochondrial membrane.

Bibliography

Amunts, A., Brown, A., Bai, X., Llácer, J. L., Hussain, T., Emsley, P., Long, F., Murshudov, G., Scheres, S. H. W., & Ramakrishnan, V. (2014). Structure of the Yeast Mitochondrial Large Ribosomal Subunit. Science, 343(6178), 1485–1489.

Authors 10
  1. Alexey Amunts (first)
  2. Alan Brown (additional)
  3. Xiao-chen Bai (additional)
  4. Jose L. Llácer (additional)
  5. Tanweer Hussain (additional)
  6. Paul Emsley (additional)
  7. Fei Long (additional)
  8. Garib Murshudov (additional)
  9. Sjors H. W. Scheres (additional)
  10. V. Ramakrishnan (additional)
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Dates
Type When
Created 11 years, 4 months ago (March 27, 2014, 2:25 p.m.)
Deposited 1 year, 7 months ago (Jan. 10, 2024, 9:57 a.m.)
Indexed 2 weeks ago (Aug. 6, 2025, 8:17 a.m.)
Issued 11 years, 4 months ago (March 28, 2014)
Published 11 years, 4 months ago (March 28, 2014)
Published Print 11 years, 4 months ago (March 28, 2014)
Funders 0

None

@article{Amunts_2014, title={Structure of the Yeast Mitochondrial Large Ribosomal Subunit}, volume={343}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1249410}, DOI={10.1126/science.1249410}, number={6178}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Amunts, Alexey and Brown, Alan and Bai, Xiao-chen and Llácer, Jose L. and Hussain, Tanweer and Emsley, Paul and Long, Fei and Murshudov, Garib and Scheres, Sjors H. W. and Ramakrishnan, V.}, year={2014}, month=mar, pages={1485–1489} }