DOI: 10.1126/science.1244142. Serial Femtosecond Crystallography of G Protein

Serial Femtosecond Crystallography of G Protein–Coupled Receptors

10.1126/science.1244142

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

G Structures G protein–coupled receptors (GPCRs) are eukaryotic membrane proteins that have a central role in cellular communication and have become key drug targets. To overcome the difficulties of growing GPCRs crystals, Liu et al. (p. 1521 ) used an x-ray free-electron laser to determine a high-resolution structure of the serotonin receptor from microcrystals.

Bibliography

Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N. A., Li, D., Messerschmidt, M., Boutet, S., Williams, G. J., Koglin, J. E., Seibert, M. M., Wang, C., Shah, S. T. A., â¦ Cherezov, V. (2013). Serial Femtosecond Crystallography of G ProteinâCoupled Receptors. Science, 342(6165), 1521â1524.

Authors 33

Wei Liu (first)
Daniel Wacker (additional)
Cornelius Gati (additional)
Gye Won Han (additional)
Daniel James (additional)
Dingjie Wang (additional)
Garrett Nelson (additional)
Uwe Weierstall (additional)
Vsevolod Katritch (additional)
Anton Barty (additional)
Nadia A. Zatsepin (additional)
Dianfan Li (additional)
Marc Messerschmidt (additional)
Sébastien Boutet (additional)
Garth J. Williams (additional)
Jason E. Koglin (additional)
M. Marvin Seibert (additional)
Chong Wang (additional)
Syed T. A. Shah (additional)
Shibom Basu (additional)
Raimund Fromme (additional)
Christopher Kupitz (additional)
Kimberley N. Rendek (additional)
Ingo Grotjohann (additional)
Petra Fromme (additional)
Richard A. Kirian (additional)
Kenneth R. Beyerlein (additional)
Thomas A. White (additional)
Henry N. Chapman (additional)
Martin Caffrey (additional)
John C. H. Spence (additional)
Raymond C. Stevens (additional)
Vadim Cherezov (additional)

References 38 Referenced 421

Dates

Type	When
Created	11 years, 8 months ago (Dec. 19, 2013, 2:17 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:51 a.m.)
Indexed	1 month ago (July 19, 2025, 11:37 p.m.)
Issued	11 years, 8 months ago (Dec. 20, 2013)
Published	11 years, 8 months ago (Dec. 20, 2013)
Published Print	11 years, 8 months ago (Dec. 20, 2013)

Funders 0

None

BibTeX

@article{Liu_2013, title={Serial Femtosecond Crystallography of G Protein–Coupled Receptors}, volume={342}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1244142}, DOI={10.1126/science.1244142}, number={6165}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Liu, Wei and Wacker, Daniel and Gati, Cornelius and Han, Gye Won and James, Daniel and Wang, Dingjie and Nelson, Garrett and Weierstall, Uwe and Katritch, Vsevolod and Barty, Anton and Zatsepin, Nadia A. and Li, Dianfan and Messerschmidt, Marc and Boutet, Sébastien and Williams, Garth J. and Koglin, Jason E. and Seibert, M. Marvin and Wang, Chong and Shah, Syed T. A. and Basu, Shibom and Fromme, Raimund and Kupitz, Christopher and Rendek, Kimberley N. and Grotjohann, Ingo and Fromme, Petra and Kirian, Richard A. and Beyerlein, Kenneth R. and White, Thomas A. and Chapman, Henry N. and Caffrey, Martin and Spence, John C. H. and Stevens, Raymond C. and Cherezov, Vadim}, year={2013}, month=dec, pages={1521–1524} }

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