DOI: 10.1126/science.1243550. Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts

Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts

10.1126/science.1243550

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Lighter Hydrogenation Catalysts Enzymes have evolved to use abundant metals such as iron, cobalt, and nickel for redox catalysis. However, synthetic catalysis has generally relied on the rarer, heavier relatives of these elements: ruthenium, rhodium, iridium, palladium, and platinum (see the Perspective by Bullock ). Friedfeld et al. (p. 1076 ) used high-throughput screening to show that the right cobalt precursor can be activated for asymmetric hydrogenation catalysis by using the traditional ligands developed for the precious metals. Zuo et al. (p. 1080 ) focused on iron, demonstrating a highly effective asymmetric transfer hydrogenation catalyst that uses a ligand rationally designed after careful mechanistic study. Jagadeesh et al. (p. 1073 ) prepared supported iron catalysts that selectively reduce nitro substituents on aromatic rings to amines, thereby facilitating the preparation of a wide range of aniline derivatives.

Bibliography

Friedfeld, M. R., Shevlin, M., Hoyt, J. M., Krska, S. W., Tudge, M. T., & Chirik, P. J. (2013). Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts. Science, 342(6162), 1076â1080.

Authors 6

Max R. Friedfeld (first)
Michael Shevlin (additional)
Jordan M. Hoyt (additional)
Shane W. Krska (additional)
Matthew T. Tudge (additional)
Paul J. Chirik (additional)

References 44 Referenced 358

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Dates

Type	When
Created	11 years, 9 months ago (Nov. 28, 2013, 2:20 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:34 a.m.)
Indexed	6 days, 18 hours ago (Aug. 28, 2025, 8:45 a.m.)
Issued	11 years, 9 months ago (Nov. 29, 2013)
Published	11 years, 9 months ago (Nov. 29, 2013)
Published Print	11 years, 9 months ago (Nov. 29, 2013)

Funders 0

None

BibTeX

@article{Friedfeld_2013, title={Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts}, volume={342}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1243550}, DOI={10.1126/science.1243550}, number={6162}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Friedfeld, Max R. and Shevlin, Michael and Hoyt, Jordan M. and Krska, Shane W. and Tudge, Matthew T. and Chirik, Paul J.}, year={2013}, month=nov, pages={1076–1080} }

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