DOI: 10.1126/science.1237933. Infectious Etiology of Neuritic (Senile) Plaques in Mice

Infectious Etiology of Neuritic (Senile) Plaques in Mice

10.1126/science.1237933

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Brains of inbred female VM mice infected with scrapie agent were studied with the use of the Bodian silver impregnation method and by electron microscopy. In brains affected with scrapie, after an incubation period of between 587 and 655 days, numerous primitive, classical, and amyloid plaques were found. No plaques of any type were seen in the control mice.

Bibliography

WiÅniewski, H. M., Bruce, M. E., & Fraser, H. (1975). Infectious Etiology of Neuritic (Senile) Plaques in Mice. Science, 190(4219), 1108â1110.

Authors 3

Henryk M. Wiśniewski (first)
Moira E. Bruce (additional)
Hugh Fraser (additional)

References 15 Referenced 101

BRUCE, M.E., AMYLOID PLAQUES IN BRAINS OF MICE INFECTED WITH SCRAPIE - MORPHOLOGICAL VARIATION AND STAINING PROPERTIES, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 1: 189 (1975). (10.1111/j.1365-2990.1975.tb00388.x) / NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (1975)
Dickinson A. G. Genetics in press.
FRASER, H, SCRAPIE IN MICE - AGENT-STRAIN DIFFERENCES IN DISTRIBUTION AND INTENSITY OF GREY MATTER VACUOLATION, JOURNAL OF COMPARATIVE PATHOLOGY 83: 29 (1973). (10.1016/0021-9975(73)90024-8) / JOURNAL OF COMPARATIVE PATHOLOGY (1973)
FRASER, H, ARGYROPHILIC PLAQUES IN MICE INOCULATED WITH SCRAPIE FROM PARTICULAR SOURCES, LANCET 1: 617 (1973). / LANCET (1973)
GARDINER, A.C., RES VET SCI 7: 190 (1965). / RES VET SCI (1965)
GLENNER, G.G., IMMUNOGLOBULIN ORIGIN OF AMYLOID, AMERICAN JOURNAL OF MEDICINE 52: 141 (1972). (10.1016/0002-9343(72)90063-0) / AMERICAN JOURNAL OF MEDICINE (1972)
NARANG, H.K., ELECTRON-MICROSCOPIC STUDY OF SCRAPIE MOUSE AND RAT - FURTHER OBSERVATIONS ON VIRUS-LIKE PARTICLES WITH RUTHENIUM RED AND LANTHANUM NITRATE AS A POSSIBLE TRACE AND NEGATIVE STAIN, NEUROBIOLOGY 4: 349 (1974). / NEUROBIOLOGY (1974)
PORTER, D.D., FAILURE TO DEMONSTRATE A HUMORAL IMMUNE-RESPONSE TO SCRAPIE INFECTION IN MICE, JOURNAL OF IMMUNOLOGY 111: 1407 (1973). (10.4049/jimmunol.111.5.1407) / JOURNAL OF IMMUNOLOGY (1973)
Schwartz P. Amyloidosis: Cause and Manifestation of Senile Deterioration (1970).
SHIRAHAMA, T, A CONGO RED STAINING METHOD FOR EPOXY-EMBEDDED AMYLOID, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 14: 725 (1966). (10.1177/14.10.725) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1966)
Terry, R. D., Ciba Foundation Symposium on Alzheimer's Disease and Related Conditions: 145 (1970). / Ciba Foundation Symposium on Alzheimer's Disease and Related Conditions (1970)
TOMLINSON, B.E., OBSERVATIONS ON BRAINS OF NON-DEMENTED OLD PEOPLE, JOURNAL OF THE NEUROLOGICAL SCIENCES 7: 331 (1968). (10.1016/0022-510X(68)90154-8) / JOURNAL OF THE NEUROLOGICAL SCIENCES (1968)
WISNIEWSKI, H, SENILE PLAQUES AND CEREBRAL AMYLOIDOSIS IN AGED DOGS - A HISTOCHEMICAL AND ULTRASTRUCTURAL STUDY, LABORATORY INVESTIGATION 23: 287 (1970). / LABORATORY INVESTIGATION (1970)
WISNIEWSKI, H.M., NEURITIC SENILE PLAQUES AND FILAMENTOUS CHANGES IN AGED RHESUS-MONKEYS, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 32: 566 (1973). (10.1097/00005072-197310000-00007) / JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (1973)
WISNIEWSKI, H.M., PROGR BRAIN RESEARCH 40: 167 (1973). (10.1016/S0079-6123(08)60686-X) / PROGR BRAIN RESEARCH (1973)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 11:11 a.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 8:50 a.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:45 a.m.)
Issued	49 years, 8 months ago (Dec. 12, 1975)
Published	49 years, 8 months ago (Dec. 12, 1975)
Published Print	49 years, 8 months ago (Dec. 12, 1975)

Funders 0

None

BibTeX

@article{Wi_niewski_1975, title={Infectious Etiology of Neuritic (Senile) Plaques in Mice}, volume={190}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1237933}, DOI={10.1126/science.1237933}, number={4219}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wiśniewski, Henryk M. and Bruce, Moira E. and Fraser, Hugh}, year={1975}, month=dec, pages={1108–1110} }

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