DOI: 10.1126/science.1219021. The Protein-Folding Problem, 50 Years On

The Protein-Folding Problem, 50 Years On

10.1126/science.1219021

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Protein Folding: Past and Future Fifty years ago the Nobel Prize in chemistry was awarded to Max Perutz and John Kendrew for determining the structure of globular proteins. Since first viewing their structure of myoglobin, scientists have sought to understand protein folding. Dill and MacCallum (p. 1042 ) review the progress that has been made on three central questions: What is the code that relates sequence to structure? How do proteins fold so fast? Can protein structure be computationally predicted? While we have come some way toward answering these questions, new questions have been gene rated. It is no longer useful to talk about “solving the protein-folding problem”—protein folding has grown into a field of research where the next 50 years promise to be as exciting as the last.

Bibliography

Dill, K. A., & MacCallum, J. L. (2012). The Protein-Folding Problem, 50 Years On. Science, 338(6110), 1042â1046.

Authors 2

Ken A. Dill (first)
Justin L. MacCallum (additional)

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Dates

Type	When
Created	12 years, 9 months ago (Nov. 22, 2012, 2:24 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:52 a.m.)
Indexed	27 minutes ago (Aug. 25, 2025, 10:53 p.m.)
Issued	12 years, 9 months ago (Nov. 23, 2012)
Published	12 years, 9 months ago (Nov. 23, 2012)
Published Print	12 years, 9 months ago (Nov. 23, 2012)

Funders 0

None

BibTeX

@article{Dill_2012, title={The Protein-Folding Problem, 50 Years On}, volume={338}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1219021}, DOI={10.1126/science.1219021}, number={6110}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Dill, Ken A. and MacCallum, Justin L.}, year={2012}, month=nov, pages={1042–1046} }

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