DOI: 10.1126/science.1217643. Integrated Electromicrobial Conversion of CO <sub>2</sub> to Higher Alcohols

Integrated Electromicrobial Conversion of CO 2 to Higher Alcohols

10.1126/science.1217643

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

An engineered microbe transforms carbon dioxide into a prospective liquid fuel in tandem with electrical power rather than light.

Bibliography

Li, H., Opgenorth, P. H., Wernick, D. G., Rogers, S., Wu, T.-Y., Higashide, W., Malati, P., Huo, Y.-X., Cho, K. M., & Liao, J. C. (2012). Integrated Electromicrobial Conversion of CO 2 to Higher Alcohols. Science, 335(6076), 1596â1596.

Authors 10

Han Li (first)
Paul H. Opgenorth (additional)
David G. Wernick (additional)
Steve Rogers (additional)
Tung-Yun Wu (additional)
Wendy Higashide (additional)
Peter Malati (additional)
Yi-Xin Huo (additional)
Kwang Myung Cho (additional)
James C. Liao (additional)

References 22 Referenced 663

10.1126/science.1200165
10.1016/0013-4686(71)80028-2
10.1246/bcsj.60.2517
10.1038/nature06450
10.1007/s00253-009-2085-6
Touati D., Transcriptional and posttranscriptional regulation of manganese superoxide dismutase biosynthesis in Escherichia coli, studied with operon and protein fusions. J. Bacteriol. 170, 2511 (1988).3131302 (10.1128/jb.170.6.2511-2520.1988) / J. Bacteriol. / Transcriptional and posttranscriptional regulation of manganese superoxide dismutase biosynthesis in Escherichia coli, studied with operon and protein fusions by Touati D. (1988)
Michán C., Manchado M., Dorado G., Pueyo C., In vivo transcription of the Escherichia coli oxyR regulon as a function of growth phase and in response to oxidative stress. J. Bacteriol. 181, 2759 (1999).10217765 (10.1128/JB.181.9.2759-2764.1999) / J. Bacteriol. / In vivo transcription of the Escherichia coli oxyR regulon as a function of growth phase and in response to oxidative stress by Michán C. (1999)
10.1046/j.1365-2958.2000.02157.x
10.1007/s11244-008-9047-6
Jeffke T., et al.., Mutational analysis of the cbb operon (CO2 assimilation) promoter of Ralstonia eutropha. J. Bacteriol. 181, 4374 (1999).10400596 (10.1128/JB.181.14.4374-4380.1999) / J. Bacteriol. / Mutational analysis of the cbb operon (CO2 assimilation) promoter of Ralstonia eutropha by Jeffke T. (1999)
Lenz O., Schwartz E., Dernedde J., Eitinger M., Friedrich B., The Alcaligenes eutrophus H16 hoxX gene participates in hydrogenase regulation. J. Bacteriol. 176, 4385 (1994).8021224 (10.1128/jb.176.14.4385-4393.1994) / J. Bacteriol. / The Alcaligenes eutrophus H16 hoxX gene participates in hydrogenase regulation by Lenz O. (1994)
10.1159/000142893
10.1007/BF00405400
10.1038/nmeth.1318
10.1007/BF00422356
10.1038/nbt.1586
10.1128/AEM.71.1.423-427.2005
10.1021/es0604313
10.1016/0022-0728(85)80008-5
10.1149/1.2405851
Finn R. K., Halvorson H. O., Sadoff H. L., Electrolysis as a means of aerating submerged cultures of microorganisms. Appl. Microbiol. 4, 164 (1956).13355395 (10.1128/am.4.4.164-170.1956) / Appl. Microbiol. / Electrolysis as a means of aerating submerged cultures of microorganisms by Finn R. K. (1956)
10.1038/205308b0

Dates

Type	When
Created	13 years, 4 months ago (March 29, 2012, 4:39 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 10:36 a.m.)
Indexed	28 minutes ago (Aug. 26, 2025, 12:33 a.m.)
Issued	13 years, 4 months ago (March 30, 2012)
Published	13 years, 4 months ago (March 30, 2012)
Published Print	13 years, 4 months ago (March 30, 2012)

Funders 0

None

BibTeX

@article{Li_2012, title={Integrated Electromicrobial Conversion of CO 2 to Higher Alcohols}, volume={335}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1217643}, DOI={10.1126/science.1217643}, number={6076}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Li, Han and Opgenorth, Paul H. and Wernick, David G. and Rogers, Steve and Wu, Tung-Yun and Higashide, Wendy and Malati, Peter and Huo, Yi-Xin and Cho, Kwang Myung and Liao, James C.}, year={2012}, month=mar, pages={1596–1596} }

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