DOI: 10.1126/science.1216753. Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice

Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice

10.1126/science.1216753

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Gene Expression by Remote ControlTechniques that allow remote, noninvasive activation of specific genes in specific tissues could one day be applied to regulate expression of therapeutic proteins in a clinical setting. In a proof-of-concept study,Stanleyet al.(p.604) showed that heating of iron oxide nanoparticles by radiowaves can remotely activate insulin gene expression in cultured cells and in a mouse model. Heating of membrane-targeted nanoparticles induced opening of a temperature-sensitive membrane channel in the cells and triggered calcium entry. The intracellular calcium signal in turn stimulated expression of an engineered insulin gene, leading to the synthesis and release of insulin. In experiments with mice bearing tumors that expressed the engineered insulin gene, exposure to radiowaves promoted secretion of insulin from the tumors and lowered blood glucose levels in the animals.

Bibliography

Stanley, S. A., Gagner, J. E., Damanpour, S., Yoshida, M., Dordick, J. S., & Friedman, J. M. (2012). Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice. Science, 336(6081), 604â608.

Authors 6

Sarah A. Stanley (first)
Jennifer E. Gagner (additional)
Shadi Damanpour (additional)
Mitsukuni Yoshida (additional)
Jonathan S. Dordick (additional)
Jeffrey M. Friedman (additional)

References 35 Referenced 430

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Dates

Type	When
Created	13 years, 4 months ago (May 3, 2012, 2:11 p.m.)
Deposited	5 months, 1 week ago (March 26, 2025, 11:44 p.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:45 a.m.)
Issued	13 years, 4 months ago (May 4, 2012)
Published	13 years, 4 months ago (May 4, 2012)
Published Print	13 years, 4 months ago (May 4, 2012)

Funders 0

None

BibTeX

@article{Stanley_2012, title={Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice}, volume={336}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1216753}, DOI={10.1126/science.1216753}, number={6081}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Stanley, Sarah A. and Gagner, Jennifer E. and Damanpour, Shadi and Yoshida, Mitsukuni and Dordick, Jonathan S. and Friedman, Jeffrey M.}, year={2012}, month=may, pages={604–608} }

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