DOI: 10.1126/science.1214100. Asymmetric Segregation of Polarized Antigen on B Cell Division Shapes Presentation Capacity

Asymmetric Segregation of Polarized Antigen on B Cell Division Shapes Presentation Capacity

10.1126/science.1214100

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Antigen Polarity in B Cell Differentiation Communication received through cell contact is critical for the differentiation of specialized effector cell populations during the immune response. For example, B lymphocytes acquire antigen that they present to helper T lymphocytes. T lymphocytes, in turn, provide key differentiation signals to B lymphocytes. In order to learn more about this process, Thaunat et al. (p. 475 ; see the Perspective by Dustin and Meyer-Hermann ) used multiphoton microscopy and imaging flow cytometry to visualize the localization of antigen in B lymphocytes during an immune response. Antigen acquired by B lymphocytes exhibited a polarized distribution that was sustained over several rounds of cell division. This produced a population of activated B lymphocytes that contained very low levels of antigen. Daughter cells that received more antigen were better able to stimulate T cells. Because cues received through T lymphocyte interactions are likely to influence B lymphocyte fate decisions, unequal distribution of antigen in dividing B lymphocytes may influence their differentiation.

Bibliography

Thaunat, O., Granja, A. G., Barral, P., Filby, A., Montaner, B., Collinson, L., Martinez-Martin, N., Harwood, N. E., Bruckbauer, A., & Batista, F. D. (2012). Asymmetric Segregation of Polarized Antigen on B Cell Division Shapes Presentation Capacity. Science, 335(6067), 475â479.

Authors 10

Olivier Thaunat (first)
Aitor G. Granja (additional)
Patricia Barral (additional)
Andrew Filby (additional)
Beatriz Montaner (additional)
Lucy Collinson (additional)
Nuria Martinez-Martin (additional)
Naomi E. Harwood (additional)
Andreas Bruckbauer (additional)
Facundo D. Batista (additional)

References 42 Referenced 130

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Dates

Type	When
Created	13 years, 7 months ago (Jan. 26, 2012, 2:27 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:40 a.m.)
Indexed	1 month ago (July 28, 2025, 5:58 p.m.)
Issued	13 years, 7 months ago (Jan. 27, 2012)
Published	13 years, 7 months ago (Jan. 27, 2012)
Published Print	13 years, 7 months ago (Jan. 27, 2012)

Funders 0

None

BibTeX

@article{Thaunat_2012, title={Asymmetric Segregation of Polarized Antigen on B Cell Division Shapes Presentation Capacity}, volume={335}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1214100}, DOI={10.1126/science.1214100}, number={6067}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Thaunat, Olivier and Granja, Aitor G. and Barral, Patricia and Filby, Andrew and Montaner, Beatriz and Collinson, Lucy and Martinez-Martin, Nuria and Harwood, Naomi E. and Bruckbauer, Andreas and Batista, Facundo D.}, year={2012}, month=jan, pages={475–479} }

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  "abstract": "<jats:title>Antigen Polarity in B Cell Differentiation</jats:title>\n          <jats:p>\n            Communication received through cell contact is critical for the differentiation of specialized effector cell populations during the immune response. For example, B lymphocytes acquire antigen that they present to helper T lymphocytes. T lymphocytes, in turn, provide key differentiation signals to B lymphocytes. In order to learn more about this process,\n            <jats:bold>\n              Thaunat\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"475\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126/science.1214100\">475</jats:related-article>\n            ; see the Perspective by\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6067\" page=\"408\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126/science.1218165\">\n              <jats:bold>Dustin and Meyer-Hermann</jats:bold>\n            </jats:related-article>\n            ) used multiphoton microscopy and imaging flow cytometry to visualize the localization of antigen in B lymphocytes during an immune response. Antigen acquired by B lymphocytes exhibited a polarized distribution that was sustained over several rounds of cell division. This produced a population of activated B lymphocytes that contained very low levels of antigen. Daughter cells that received more antigen were better able to stimulate T cells. Because cues received through T lymphocyte interactions are likely to influence B lymphocyte fate decisions, unequal distribution of antigen in dividing B lymphocytes may influence their differentiation.\n          </jats:p>",
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