DOI: 10.1126/science.1198095. Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

10.1126/science.1198095

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Two hypolipidemic compounds [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid, and 2-chloro-5-(3,5-dimethylpiperidinosulfonyl)benzoic acid (tibric acid) greatly increased the number of peroxisomes (microbodies) in liver cells of rats and mice. This augmented peroxisome population was accompanied by significant elevation of liver catalase activity. These two hypolipidemic peroxisome proliferators are structurally different from ethyl α- p -chlorophenozyisobutyrate (clofibrate) and other hypolipidemic, aryloxyisobutyrate derivatives which cause hepatic peroxisome proliferation. Induction of peroxisome proliferation by these structurally unrelated hypolipidemic compounds suggests a possible relation between hepatic peroxisome proliferation and hypolipidemia.

Bibliography

Reddy, J. K., & Krishnakantha, T. P. (1975). Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate. Science, 190(4216), 787â789.

Authors 2

Janardan K. Reddy (first)
T. P. Krishnakantha (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 11:11 a.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:59 a.m.)
Indexed	4 months, 1 week ago (April 21, 2025, 5:43 p.m.)
Issued	49 years, 9 months ago (Nov. 21, 1975)
Published	49 years, 9 months ago (Nov. 21, 1975)
Published Print	49 years, 9 months ago (Nov. 21, 1975)

Funders 0

None

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