DOI: 10.1126/science.1185547. Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures [Penn]

Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures

10.1126/science.1185547

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Janus Drug Delivery Vehicle Efficient drug delivery vehicles need to be produced in a limited size range and with uniform size distribution. The self-assembly of traditional small-molecule and polymeric amphiphiles has led to the production of micelles, liposomes, polymeric micelles, and polymersomes for use in drug delivery applications. Now, Percec et al. (p. 1009 ) describe the self-assembly of Janus-type (i.e., two-headed) dendrimers to produce monodisperse supramolecular constructs, termed “dendrimersomes,” and other complex architectures. The structures, which showed long-term stability as well as very narrow size distributions, were easily produced by the injection of an ethanolic solution of the dendrimer into water. The dendrimersomes could be loaded with the anticancer drug doxorubicin and exhibited controlled drug release with changing pH.

Bibliography

Percec, V., Wilson, D. A., Leowanawat, P., Wilson, C. J., Hughes, A. D., Kaucher, M. S., Hammer, D. A., Levine, D. H., Kim, A. J., Bates, F. S., Davis, K. P., Lodge, T. P., Klein, M. L., DeVane, R. H., Aqad, E., Rosen, B. M., Argintaru, A. O., Sienkowska, M. J., Rissanen, K., â¦ Ropponen, J. (2010). Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures. Science, 328(5981), 1009â1014.

Authors 21

Virgil Percec (first)
Daniela A. Wilson (additional)
Pawaret Leowanawat (additional)
Christopher J. Wilson (additional)
Andrew D. Hughes (additional)
Mark S. Kaucher (additional)
Daniel A. Hammer (additional)
Dalia H. Levine (additional)
Anthony J. Kim (additional)
Frank S. Bates (additional)
Kevin P. Davis (additional)
Timothy P. Lodge (additional)
Michael L. Klein (additional)
Russell H. DeVane (additional)
Emad Aqad (additional)
Brad M. Rosen (additional)
Andreea O. Argintaru (additional)
Monika J. Sienkowska (additional)
Kari Rissanen (additional)
Sami Nummelin (additional)
Jarmo Ropponen (additional)

References 35 Referenced 686

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Dates

Type	When
Created	15 years, 3 months ago (May 20, 2010, 1:35 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 3:06 a.m.)
Indexed	1 week, 5 days ago (Aug. 12, 2025, 5:34 p.m.)
Issued	15 years, 3 months ago (May 21, 2010)
Published	15 years, 3 months ago (May 21, 2010)
Published Print	15 years, 3 months ago (May 21, 2010)

Funders 0

None

BibTeX

@article{Percec_2010, title={Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures}, volume={328}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1185547}, DOI={10.1126/science.1185547}, number={5981}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Percec, Virgil and Wilson, Daniela A. and Leowanawat, Pawaret and Wilson, Christopher J. and Hughes, Andrew D. and Kaucher, Mark S. and Hammer, Daniel A. and Levine, Dalia H. and Kim, Anthony J. and Bates, Frank S. and Davis, Kevin P. and Lodge, Timothy P. and Klein, Michael L. and DeVane, Russell H. and Aqad, Emad and Rosen, Brad M. and Argintaru, Andreea O. and Sienkowska, Monika J. and Rissanen, Kari and Nummelin, Sami and Ropponen, Jarmo}, year={2010}, month=may, pages={1009–1014} }

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  "abstract": "<jats:title>Janus Drug Delivery Vehicle</jats:title>\n          <jats:p>\n            Efficient drug delivery vehicles need to be produced in a limited size range and with uniform size distribution. The self-assembly of traditional small-molecule and polymeric amphiphiles has led to the production of micelles, liposomes, polymeric micelles, and polymersomes for use in drug delivery applications. Now,\n            <jats:bold>\n              Percec\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"1009\" related-article-type=\"in-this-issue\" vol=\"328\" xlink:href=\"10.1126/science.1185547\">1009</jats:related-article>\n            ) describe the self-assembly of Janus-type (i.e., two-headed) dendrimers to produce monodisperse supramolecular constructs, termed \u201cdendrimersomes,\u201d and other complex architectures. The structures, which showed long-term stability as well as very narrow size distributions, were easily produced by the injection of an ethanolic solution of the dendrimer into water. The dendrimersomes could be loaded with the anticancer drug doxorubicin and exhibited controlled drug release with changing pH.\n          </jats:p>",
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