DOI: 10.1126/science.1183021. Regulation of Adaptive Immunity by the Innate Immune System

Regulation of Adaptive Immunity by the Innate Immune System

10.1126/science.1183021

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Twenty years after the proposal that pattern recognition receptors detect invasion by microbial pathogens, the field of immunology has witnessed several discoveries that have elucidated receptors and signaling pathways of microbial recognition systems and how they control the generation of T and B lymphocyte–mediated immune responses. However, there are still many fundamental questions that remain poorly understood, even though sometimes the answers are assumed to be known. Here, we discuss some of these questions, including the mechanisms by which pathogen-specific innate immune recognition activates antigen-specific adaptive immune responses and the roles of different types of innate immune recognition in host defense from infection and injury.

Bibliography

Iwasaki, A., & Medzhitov, R. (2010). Regulation of Adaptive Immunity by the Innate Immune System. Science, 327(5963), 291â295.

Authors 2

Akiko Iwasaki (first)
Ruslan Medzhitov (additional)

References 59 Referenced 1,668

Dates

Type	When
Created	15 years, 7 months ago (Jan. 14, 2010, 2:38 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 4:10 a.m.)
Indexed	3 hours, 33 minutes ago (Aug. 31, 2025, 7:17 p.m.)
Issued	15 years, 7 months ago (Jan. 15, 2010)
Published	15 years, 7 months ago (Jan. 15, 2010)
Published Print	15 years, 7 months ago (Jan. 15, 2010)

Funders 0

None

BibTeX

@article{Iwasaki_2010, title={Regulation of Adaptive Immunity by the Innate Immune System}, volume={327}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1183021}, DOI={10.1126/science.1183021}, number={5963}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Iwasaki, Akiko and Medzhitov, Ruslan}, year={2010}, month=jan, pages={291–295} }

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