DOI: 10.1126/science.1155307. Divergence of Quaternary Structures Among Bacterial Flagellar Filaments

Divergence of Quaternary Structures Among Bacterial Flagellar Filaments

10.1126/science.1155307

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium . The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori , which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5.

Bibliography

Galkin, V. E., Yu, X., Bielnicki, J., Heuser, J., Ewing, C. P., Guerry, P., & Egelman, E. H. (2008). Divergence of Quaternary Structures Among Bacterial Flagellar Filaments. Science, 320(5874), 382â385.

Authors 7

Vitold E. Galkin (first)
Xiong Yu (additional)
Jakub Bielnicki (additional)
John Heuser (additional)
Cheryl P. Ewing (additional)
Patricia Guerry (additional)
Edward H. Egelman (additional)

References 28 Referenced 96

10.1006/jmbi.2000.3741
10.1016/j.sbi.2005.05.005
M. K. Frank, F. Dyda, A. Dobrodumov, A. M. Gronenborn, Nat. Struct. Biol.9, 877 (2002). / Nat. Struct. Biol. (2002)
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This work was supported by NIH grants EB001567 (E.H.E.) and AI043559 (P.G.). The electron microscopic reconstruction has been deposited in the Electron Microscopy Data Base with accession code EMD-5007.

Dates

Type	When
Created	17 years, 4 months ago (April 17, 2008, 6:31 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 4:24 a.m.)
Indexed	2 months, 1 week ago (June 20, 2025, 2:24 p.m.)
Issued	17 years, 4 months ago (April 18, 2008)
Published	17 years, 4 months ago (April 18, 2008)
Published Print	17 years, 4 months ago (April 18, 2008)

Funders 0

None

BibTeX

@article{Galkin_2008, title={Divergence of Quaternary Structures Among Bacterial Flagellar Filaments}, volume={320}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1155307}, DOI={10.1126/science.1155307}, number={5874}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Galkin, Vitold E. and Yu, Xiong and Bielnicki, Jakub and Heuser, John and Ewing, Cheryl P. and Guerry, Patricia and Egelman, Edward H.}, year={2008}, month=apr, pages={382–385} }

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