Carbon Dioxide Activation at the Ni,Fe-Cluster of Anaerobic Carbon Monoxide Dehydrogenase
10.1126/science.1148481
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Anaerobic CO dehydrogenases catalyze the reversible oxidation of CO to CO 2 at a complex Ni-, Fe-, and S-containing metal center called cluster C. We report crystal structures of CO dehydrogenase II from Carboxydothermus hydrogenoformans in three different states. In a reduced state, exogenous CO 2 supplied in solution is bound and reductively activated by cluster C. In the intermediate structure, CO 2 acts as a bridging ligand between Ni and the asymmetrically coordinated Fe, where it completes the square-planar coordination of the Ni ion. It replaces a water/hydroxo ligand bound to the Fe ion in the other two states. The structures define the mechanism of CO oxidation and CO 2 reduction at the Ni-Fe site of cluster C.

Bibliography

Jeoung, J.-H., & Dobbek, H. (2007). Carbon Dioxide Activation at the Ni,Fe-Cluster of Anaerobic Carbon Monoxide Dehydrogenase. Science, 318(5855), 1461–1464.

Authors 2
  1. Jae-Hun Jeoung (first)
  2. Holger Dobbek (additional)
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Dates
Type When
Created 17 years, 9 months ago (Nov. 29, 2007, 5:33 p.m.)
Deposited 1 year, 7 months ago (Jan. 10, 2024, 3:38 a.m.)
Indexed 1 day, 17 hours ago (Aug. 31, 2025, 6:04 a.m.)
Issued 17 years, 9 months ago (Nov. 30, 2007)
Published 17 years, 9 months ago (Nov. 30, 2007)
Published Print 17 years, 9 months ago (Nov. 30, 2007)
Funders 0

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@article{Jeoung_2007, title={Carbon Dioxide Activation at the Ni,Fe-Cluster of Anaerobic Carbon Monoxide Dehydrogenase}, volume={318}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1148481}, DOI={10.1126/science.1148481}, number={5855}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Jeoung, Jae-Hun and Dobbek, Holger}, year={2007}, month=nov, pages={1461–1464} }