DOI: 10.1126/science.1146885. Muscular Thin Films for Building Actuators and Powering Devices

Muscular Thin Films for Building Actuators and Powering Devices

10.1126/science.1146885

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

We demonstrate the assembly of biohybrid materials from engineered tissues and synthetic polymer thin films. The constructs were built by culturing neonatal rat ventricular cardiomyocytes on polydimethylsiloxane thin films micropatterned with extracellular matrix proteins to promote spatially ordered, two-dimensional myogenesis. The constructs, termed muscular thin films, adopted functional, three-dimensional conformations when released from a thermally sensitive polymer substrate and were designed to perform biomimetic tasks by varying tissue architecture, thin-film shape, and electrical-pacing protocol. These centimeter-scale constructs perform functions as diverse as gripping, pumping, walking, and swimming with fine spatial and temporal control and generating specific forces as high as 4 millinewtons per square millimeter.

Bibliography

Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007). Muscular Thin Films for Building Actuators and Powering Devices. Science, 317(5843), 1366â1370.

Authors 6

Adam W. Feinberg (first)
Alex Feigel (additional)
Sergey S. Shevkoplyas (additional)
Sean Sheehy (additional)
George M. Whitesides (additional)
Kevin Kit Parker (additional)

References 30 Referenced 669

D. M. Bers Excitation-Contraction Coupling and Cardiac Contractile Force (Kluwer Boston ed. 2 2001). (10.1007/978-94-010-0658-3)
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K. Baaret al., FASEB J.19, 275 (2005). / FASEB J. (2005)
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Materials and methods are available as supporting material on Science Online.
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10.1126/science.1109616
We acknowledge financial support from the Defense Advance Research Projects Agency's Biomolecular Motors Program the Air Force Office of Sponsored Research and the Harvard Materials Research Science and Engineering Center (MRSEC). S.S.S. and A.F. acknowledge salary support from the U.S. Army Research Office. We thank H. Stone for comments on the manuscript.

Dates

Type	When
Created	17 years, 11 months ago (Sept. 7, 2007, 12:29 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 3:10 a.m.)
Indexed	9 minutes ago (Aug. 29, 2025, 3:06 a.m.)
Issued	17 years, 11 months ago (Sept. 7, 2007)
Published	17 years, 11 months ago (Sept. 7, 2007)
Published Print	17 years, 11 months ago (Sept. 7, 2007)

Funders 0

None

BibTeX

@article{Feinberg_2007, title={Muscular Thin Films for Building Actuators and Powering Devices}, volume={317}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1146885}, DOI={10.1126/science.1146885}, number={5843}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Feinberg, Adam W. and Feigel, Alex and Shevkoplyas, Sergey S. and Sheehy, Sean and Whitesides, George M. and Parker, Kevin Kit}, year={2007}, month=sep, pages={1366–1370} }

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