DOI: 10.1126/science.1141634. A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

10.1126/science.1141634

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetesâsusceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

Bibliography

Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., Shields, B., Harries, L. W., Barrett, J. C., Ellard, S., Groves, C. J., Knight, B., Patch, A.-M., Ness, A. R., Ebrahim, S., â¦ McCarthy, M. I. (2007). A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity. Science, 316(5826), 889â894.

Authors 41

Timothy M. Frayling (first)
Nicholas J. Timpson (additional)
Michael N. Weedon (additional)
Eleftheria Zeggini (additional)
Rachel M. Freathy (additional)
Cecilia M. Lindgren (additional)
John R. B. Perry (additional)
Katherine S. Elliott (additional)
Hana Lango (additional)
Nigel W. Rayner (additional)
Beverley Shields (additional)
Lorna W. Harries (additional)
Jeffrey C. Barrett (additional)
Sian Ellard (additional)
Christopher J. Groves (additional)
Bridget Knight (additional)
Ann-Marie Patch (additional)
Andrew R. Ness (additional)
Shah Ebrahim (additional)
Debbie A. Lawlor (additional)
Susan M. Ring (additional)
Yoav Ben-Shlomo (additional)
Marjo-Riitta Jarvelin (additional)
Ulla Sovio (additional)
Amanda J. Bennett (additional)
David Melzer (additional)
Luigi Ferrucci (additional)
Ruth J. F. Loos (additional)
IneÌs Barroso (additional)
Nicholas J. Wareham (additional)
Fredrik Karpe (additional)
Katharine R. Owen (additional)
Lon R. Cardon (additional)
Mark Walker (additional)
Graham A. Hitman (additional)
Colin N. A. Palmer (additional)
Alex S. F. Doney (additional)
Andrew D. Morris (additional)
George Davey Smith (additional)
Andrew T. Hattersley (additional)
Mark I. McCarthy (additional)

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Collection of the type 2 diabetes cases was supported by Diabetes UK British Diabetic Association Research and the UK Medical Research Council (Biomedical Collections Strategic Grant G0000649). The UK Type 2 Diabetes Genetics Consortium collection was supported by the Wellcome Trust (Biomedical Collections Grant GR072960). The ALSPAC study was supported by the UK Medical Research Council (MRC) the Wellcome Trust and the University of Bristol. The British Women's Heart and Health Study was funded by the Department of Health and the British Heart Foundation. The Caerphilly study was funded by MRC and the British Heart Foundation. The Caerphilly study was undertaken by the former MRC Epidemiology Unit (South Wales) and was funded by the MRC. The data archive is maintained by the Department of Social Medicine University of Bristol. The Exeter Family Study of Childhood Health was supported by NHS Research and Development and the Wellcome Trust. The work on the Northern Finland birth cohort study was supported by the Academy of Finland (104781) MRC (G0500539) and the Wellcome Trust (Project Grant GR069224). Oxford Biobank was supported by the British Heart Foundation. The Invecchiare in Chianti (InCHIANTI) study was supported by contract funding from the U.S. National Institute on Aging (NIA) and the research was supported in part by the Intramural Research Program NIA NIH. The European Prospective Investigation of Cancer (EPIC)âNorfolk cohort study is supported by program grants from MRC and Cancer Research UK. The EPIC-Norfolk obesity case-cohort study and its genotyping was funded by the Wellcome Trust and MRC. The genome-wide association genotyping was supported by the Wellcome Trust (076113) and replication genotyping was supported by the Wellcome Trust Diabetes UK the European Commission (EURODIA LSHG-CT-2004-518153) and the Peninsula Medical School. Personal funding comes from the Wellcome Trust (A.T.H. Research Leave Fellow; I.B. Investigator; E.Z. Research Career Development Fellow; L.R.C. Principal Research Fellow); MRC (J.R.B.P.); Diabetes UK (R.M.F.); and Throne-Holst Foundation (C.M.L.). L.W.H. is a Research Councils UK Diabetes and Metabolism Academic Fellow. M.N.W. is Vandervell Foundation Research Fellow at the Peninsula Medical School. C.N.A.P. and A.D.M. are supported by the Scottish executive as part of the Generation Scotland Initiative. We acknowledge theassistance of many colleagues involved in sample collection phenotyping and DNA extraction in all the different studies. We thank K. Parnell C. Kimber A. Murray K. Northstone and C. Boustred for technical assistance. We thank S. Howell M. Murphy and A. Wilson (Diabetes UK) for their long-term support for these studies. We also acknowledge the efforts of J. Collier P. Robinson S. Asquith and others at Kbiosciences. Accession numbers for deposited sequence variants from dbSNP are Exon3_A 69374768 3_UTR_A 69374769 3_UTR_B 69374770 and 3_UTR_G 69374771.

Dates

Type	When
Created	18 years, 4 months ago (April 12, 2007, 8:49 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 3:51 a.m.)
Indexed	23 hours, 29 minutes ago (Sept. 4, 2025, 9:45 a.m.)
Issued	18 years, 3 months ago (May 11, 2007)
Published	18 years, 3 months ago (May 11, 2007)
Published Print	18 years, 3 months ago (May 11, 2007)

Funders 0

None

BibTeX

@article{Frayling_2007, title={A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity}, volume={316}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1141634}, DOI={10.1126/science.1141634}, number={5826}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Frayling, Timothy M. and Timpson, Nicholas J. and Weedon, Michael N. and Zeggini, Eleftheria and Freathy, Rachel M. and Lindgren, Cecilia M. and Perry, John R. B. and Elliott, Katherine S. and Lango, Hana and Rayner, Nigel W. and Shields, Beverley and Harries, Lorna W. and Barrett, Jeffrey C. and Ellard, Sian and Groves, Christopher J. and Knight, Bridget and Patch, Ann-Marie and Ness, Andrew R. and Ebrahim, Shah and Lawlor, Debbie A. and Ring, Susan M. and Ben-Shlomo, Yoav and Jarvelin, Marjo-Riitta and Sovio, Ulla and Bennett, Amanda J. and Melzer, David and Ferrucci, Luigi and Loos, Ruth J. F. and Barroso, IneÌs and Wareham, Nicholas J. and Karpe, Fredrik and Owen, Katharine R. and Cardon, Lon R. and Walker, Mark and Hitman, Graham A. and Palmer, Colin N. A. and Doney, Alex S. F. and Morris, Andrew D. and Smith, George Davey and Hattersley, Andrew T. and McCarthy, Mark I.}, year={2007}, month=may, pages={889–894} }

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    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        2007,
        5,
        11
      ]
    ]
  }
}