DOI: 10.1126/science.1138751. A Dinuclear Ni(µ-H)Ru Complex Derived from H <sub>2</sub>

A Dinuclear Ni(µ-H)Ru Complex Derived from H 2

10.1126/science.1138751

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Models of the active site in [NiFe]hydrogenase enzymes have proven challenging to prepare. We isolated a paramagnetic dinuclear nickel-ruthenium complex with a bridging hydrido ligand from the heterolytic cleavage of H 2 by a dinuclear NiRu aqua complex in water under ambient conditions (20°C and 1 atmosphere pressure). The structure of the hexacoordinate Ni(μ-H)Ru complex was unequivocally determined by neutron diffraction analysis, and it comes closest to an effective analog for the core structure of the proposed active form of the enzyme.

Bibliography

Ogo, S., Kabe, R., Uehara, K., Kure, B., Nishimura, T., Menon, S. C., Harada, R., Fukuzumi, S., Higuchi, Y., Ohhara, T., Tamada, T., & Kuroki, R. (2007). A Dinuclear Ni(Âµ-H)Ru Complex Derived from H 2. Science, 316(5824), 585â587.

Authors 12

Seiji Ogo (first)
Ryota Kabe (additional)
Keiji Uehara (additional)
Bunsho Kure (additional)
Takashi Nishimura (additional)
Saija C. Menon (additional)
Ryosuke Harada (additional)
Shunichi Fukuzumi (additional)
Yoshiki Higuchi (additional)
Takashi Ohhara (additional)
Taro Tamada (additional)
Ryota Kuroki (additional)

References 33 Referenced 253

R. Cammack M. Frey R. Robson Hydrogen as a Fuel: Learning from Nature (Taylor & Francis London 2001). (10.1201/9780203471043)
M. Frey, Structure and Bonding (Springer-Verlag, Berlin, 1998), pp. 97–126. / Structure and Bonding (1998)
10.1016/0005-2728(94)90036-1
10.1126/science.282.5395.1853
10.1038/373580a0
10.1021/ja962270g
10.1016/j.ccr.2005.04.011
10.1021/ja010204v
10.1021/om020724e
10.1016/j.ccr.2004.10.010
10.1039/b201317g
10.1016/S0010-8545(01)00396-4
10.1016/S0010-8545(00)00268-X
10.1021/ja051590
10.1073/pnas.0505779102
10.1021/ja027522u
10.1021/ja036624x
10.1021/om960840f
10.1021/ic00348a037
Materials and methods are available as supporting material on Science Online.
10.1021/om980711u
10.1021/ja011846l
10.1016/S0020-1693(97)05521-7
10.1002/(SICI)1099-0682(199806)1998:6<851::AID-EJIC851>3.0.CO;2-1
10.1021/cr60306a004
10.1016/j.poly.2004.12.019
10.1021/ic0155838
10.1021/ic025870r
10.1021/ja962429p
M. Peruzzini, R. Poli, Recent Advances in Hydride Chemistry (Elsevier, Amsterdam, ed. 1, 2001), pp. 139–188. / Recent Advances in Hydride Chemistry (2001)
10.1021/ja0455594
10.1021/ja010603q
This work was supported by grants in aid 17350027 19205009 18033041 and 18065017 (Chemistry of Concerto Catalysis) from the Ministry of Education Culture Sports Science and Technology Japan; and a Core Research for Evolutional Science and Technology program (Nano-Structured Catalysts and Materials) by JST. Crystallographic data for [ 1 ](OTf) 2 and [ 2 ](NO 3 ) have been deposited with the Cambridge Crystallographic Data Center under reference numbers CCDC-617674 (x-ray) 617675 (x-ray) and 637331 (neutron diffraction analysis).

Dates

Type	When
Created	18 years, 3 months ago (April 26, 2007, 4:38 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 3:39 a.m.)
Indexed	1 month ago (July 19, 2025, 11:48 p.m.)
Issued	18 years, 3 months ago (April 27, 2007)
Published	18 years, 3 months ago (April 27, 2007)
Published Print	18 years, 3 months ago (April 27, 2007)

Funders 0

None

BibTeX

@article{Ogo_2007, title={A Dinuclear Ni(µ-H)Ru Complex Derived from H 2}, volume={316}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1138751}, DOI={10.1126/science.1138751}, number={5824}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ogo, Seiji and Kabe, Ryota and Uehara, Keiji and Kure, Bunsho and Nishimura, Takashi and Menon, Saija C. and Harada, Ryosuke and Fukuzumi, Shunichi and Higuchi, Yoshiki and Ohhara, Takashi and Tamada, Taro and Kuroki, Ryota}, year={2007}, month=apr, pages={585–587} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        20
      ]
    ],
    "date-time": "2025-07-20T03:48:13Z",
    "timestamp": 1752983293064
  },
  "reference-count": 33,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "5824",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        4,
        27
      ]
    ]
  },
  "abstract": "<jats:p>\n            Models of the active site in [NiFe]hydrogenase enzymes have proven challenging to prepare. We isolated a paramagnetic dinuclear nickel-ruthenium complex with a bridging hydrido ligand from the heterolytic cleavage of H\n            <jats:sub>2</jats:sub>\n            by a dinuclear NiRu aqua complex in water under ambient conditions (20\u00b0C and 1 atmosphere pressure). The structure of the hexacoordinate Ni(\u03bc-H)Ru complex was unequivocally determined by neutron diffraction analysis, and it comes closest to an effective analog for the core structure of the proposed active form of the enzyme.\n          </jats:p>",
  "DOI": "10.1126/science.1138751",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        4,
        26
      ]
    ],
    "date-time": "2007-04-26T20:38:02Z",
    "timestamp": 1177619882000
  },
  "page": "585-587",
  "source": "Crossref",
  "is-referenced-by-count": 253,
  "title": "A Dinuclear Ni(\u00b5-H)Ru Complex Derived from H\n            <sub>2</sub>",
  "prefix": "10.1126",
  "volume": "316",
  "author": [
    {
      "given": "Seiji",
      "family": "Ogo",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Ryota",
      "family": "Kabe",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Keiji",
      "family": "Uehara",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Bunsho",
      "family": "Kure",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Takashi",
      "family": "Nishimura",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Saija C.",
      "family": "Menon",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Ryosuke",
      "family": "Harada",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Shunichi",
      "family": "Fukuzumi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Yoshiki",
      "family": "Higuchi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Takashi",
      "family": "Ohhara",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Taro",
      "family": "Tamada",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    },
    {
      "given": "Ryota",
      "family": "Kuroki",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Future Chemistry, Kyushu University, Fukuoka 819\u20130395, Japan."
        },
        {
          "name": "Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency (JST), Suita, Osaka 565\u20130871, Japan."
        },
        {
          "name": "Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto, Kamigori, Hyogo 678\u20131297, Japan."
        },
        {
          "name": "Research Group for Molecular Structural Biology, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319\u20131195, Japan."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_3_1_2_2",
      "doi-asserted-by": "crossref",
      "unstructured": "R. Cammack M. Frey R. Robson Hydrogen as a Fuel: Learning from Nature (Taylor & Francis London 2001).",
      "DOI": "10.1201/9780203471043"
    },
    {
      "key": "e_1_3_1_3_2",
      "first-page": "97",
      "year": "1998",
      "unstructured": "M. Frey, Structure and Bonding (Springer-Verlag, Berlin, 1998), pp. 97\u2013126.",
      "journal-title": "Structure and Bonding"
    },
    {
      "key": "e_1_3_1_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0005-2728(94)90036-1"
    },
    {
      "key": "e_1_3_1_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.282.5395.1853"
    },
    {
      "key": "e_1_3_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/373580a0"
    },
    {
      "key": "e_1_3_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja962270g"
    },
    {
      "key": "e_1_3_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.ccr.2005.04.011"
    },
    {
      "key": "e_1_3_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja010204v"
    },
    {
      "key": "e_1_3_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/om020724e"
    },
    {
      "key": "e_1_3_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.ccr.2004.10.010"
    },
    {
      "key": "e_1_3_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/b201317g"
    },
    {
      "key": "e_1_3_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0010-8545(01)00396-4"
    },
    {
      "key": "e_1_3_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0010-8545(00)00268-X"
    },
    {
      "key": "e_1_3_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja051590"
    },
    {
      "key": "e_1_3_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0505779102"
    },
    {
      "key": "e_1_3_1_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja027522u"
    },
    {
      "key": "e_1_3_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja036624x"
    },
    {
      "key": "e_1_3_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/om960840f"
    },
    {
      "key": "e_1_3_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ic00348a037"
    },
    {
      "key": "e_1_3_1_21_2",
      "unstructured": "Materials and methods are available as supporting material on Science Online."
    },
    {
      "key": "e_1_3_1_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/om980711u"
    },
    {
      "key": "e_1_3_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja011846l"
    },
    {
      "key": "e_1_3_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0020-1693(97)05521-7"
    },
    {
      "key": "e_1_3_1_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1099-0682(199806)1998:6<851::AID-EJIC851>3.0.CO;2-1"
    },
    {
      "key": "e_1_3_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cr60306a004"
    },
    {
      "key": "e_1_3_1_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.poly.2004.12.019"
    },
    {
      "key": "e_1_3_1_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ic0155838"
    },
    {
      "key": "e_1_3_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ic025870r"
    },
    {
      "key": "e_1_3_1_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja962429p"
    },
    {
      "key": "e_1_3_1_31_2",
      "first-page": "139",
      "year": "2001",
      "unstructured": "M. Peruzzini, R. Poli, Recent Advances in Hydride Chemistry (Elsevier, Amsterdam, ed. 1, 2001), pp. 139\u2013188.",
      "journal-title": "Recent Advances in Hydride Chemistry"
    },
    {
      "key": "e_1_3_1_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja0455594"
    },
    {
      "key": "e_1_3_1_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja010603q"
    },
    {
      "key": "e_1_3_1_34_2",
      "unstructured": "This work was supported by grants in aid 17350027 19205009 18033041 and 18065017 (Chemistry of Concerto Catalysis) from the Ministry of Education Culture Sports Science and Technology Japan; and a Core Research for Evolutional Science and Technology program (Nano-Structured Catalysts and Materials) by JST. Crystallographic data for [ 1 ](OTf) 2 and [ 2 ](NO 3 ) have been deposited with the Cambridge Crystallographic Data Center under reference numbers CCDC-617674 (x-ray) 617675 (x-ray) and 637331 (neutron diffraction analysis)."
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.1138751",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        10
      ]
    ],
    "date-time": "2024-01-10T08:39:45Z",
    "timestamp": 1704875985000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.1138751"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        4,
        27
      ]
    ]
  },
  "references-count": 33,
  "journal-issue": {
    "issue": "5824",
    "published-print": {
      "date-parts": [
        [
          2007,
          4,
          27
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.1138751"
  ],
  "URL": "http://dx.doi.org/10.1126/science.1138751",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1081955.534902",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        2007,
        4,
        27
      ]
    ]
  }
}