DOI: 10.1126/science.1137999. Disrupting the Pairing Between <i>let-7</i> and <i>Hmga2</i> Enhances Oncogenic Transformation

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

10.1126/science.1137999

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

MicroRNAs (miRNAs) are ∼22-nucleotide RNAs that can pair to sites within messenger RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA expression can contribute to tumorigenesis, but which of the many miRNA-target relationships are relevant to this process has been unclear. Here, we report that chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 ( Hmga2 ) by let-7 miRNA. This disrupted repression promotes anchorage-independent growth, a characteristic of oncogenic transformation. Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells.

Bibliography

Mayr, C., Hemann, M. T., & Bartel, D. P. (2007). Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation. Science, 315(5818), 1576â1579.

Authors 3

Christine Mayr (first)
Michael T. Hemann (additional)
David P. Bartel (additional)

References 29 Referenced 920

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We thank M. Narita and S. Lowe for providing the Hmga2 antibody and C. Jan A. Grimson and M. Narita for helpful discussions and advice. Supported by grants from the Deutsche Forschungsgemeinschaft (C.M.) and the NIH (D.B.). D.B. is a Howard Hughes Medical Institute Investigator.

Dates

Type	When
Created	18 years, 6 months ago (Feb. 22, 2007, 8:57 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 2:57 a.m.)
Indexed	3 weeks, 4 days ago (Aug. 2, 2025, 12:05 a.m.)
Issued	18 years, 5 months ago (March 16, 2007)
Published	18 years, 5 months ago (March 16, 2007)
Published Print	18 years, 5 months ago (March 16, 2007)

Funders 0

None

BibTeX

@article{Mayr_2007, title={Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation}, volume={315}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1137999}, DOI={10.1126/science.1137999}, number={5818}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Mayr, Christine and Hemann, Michael T. and Bartel, David P.}, year={2007}, month=mar, pages={1576–1579} }

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