DOI: 10.1126/science.1133212. Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery

Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery

10.1126/science.1133212

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, γ-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were triggered by oxytocin, an essential maternal hormone for labor. In vivo administration of an oxytocin receptor antagonist before delivery prevented the switch of GABA actions in fetal neurons and aggravated the severity of anoxic episodes. Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery.

Bibliography

Tyzio, R., Cossart, R., Khalilov, I., Minlebaev, M., HuÌbner, C. A., Represa, A., Ben-Ari, Y., & Khazipov, R. (2006). Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery. Science, 314(5806), 1788â1792.

Authors 8

Roman Tyzio (first)
Rosa Cossart (additional)
Ilgam Khalilov (additional)
Marat Minlebaev (additional)
Christian A. Hübner (additional)
Alfonso Represa (additional)
Yehezkel Ben-Ari (additional)
Rustem Khazipov (additional)

References 34 Referenced 390

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10.1038/nrn920
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10.1523/JNEUROSCI.19-23-10372.1999
10.1113/jphysiol.1989.sp017762
10.1038/16697
10.1523/JNEUROSCI.16-20-06414.1996
10.1113/jphysiol.1996.sp021505
10.1113/jphysiol.1995.sp020973
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10.1016/S0896-6273(00)80265-2
10.1152/jn.00172.2003
10.1046/j.1460-9568.1998.00284.x
10.1523/JNEUROSCI.07-05-01384.1987
10.1016/0896-6273(91)90243-S
10.1016/0896-6273(95)90008-X
10.1111/j.1469-7793.1998.219bu.x
10.1152/physrev.2001.81.2.629
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10.1016/S0301-0082(00)00064-2
10.1038/nn1023
10.1038/nature03701
10.1016/j.mcn.2006.01.006
10.1126/science.1105636
A. Malek, E. Blann, D. R. Mattison, J. Matern. Fetal Med.5, 245 (1996). / J. Matern. Fetal Med. (1996)
10.1007/s00424-002-0933-7
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10.1152/physrev.1999.79.4.1431
10.1016/j.neuron.2005.10.025
We thank I. Jorquera I. Chudotvorova D. Diabira and C. Pellegrino for technical assistance; K. Krnjevic M. Milh I. Medyna J. L. Gaiarsa A. Ivanov and C. Hammond for helpful comments on the manuscript; and Sanofi-Synthelabs for the gift of SSR126768A. This work was supported by INSERM Fondation pour la Recherche Médicale L`Agence Nationale de la Recherche Federation pour la Recherche sur le Cerveau and Rotary International Conseil régional Provence-Alpes-Côte d`Azur and European Community grant LSHB-CT-2004-503467.

Dates

Type	When
Created	18 years, 8 months ago (Dec. 14, 2006, 7:55 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 4:49 a.m.)
Indexed	1 week, 6 days ago (Aug. 12, 2025, 5:39 p.m.)
Issued	18 years, 8 months ago (Dec. 15, 2006)
Published	18 years, 8 months ago (Dec. 15, 2006)
Published Print	18 years, 8 months ago (Dec. 15, 2006)

Funders 0

None

BibTeX

@article{Tyzio_2006, title={Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery}, volume={314}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1133212}, DOI={10.1126/science.1133212}, number={5806}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Tyzio, Roman and Cossart, Rosa and Khalilov, Ilgam and Minlebaev, Marat and Hübner, Christian A. and Represa, Alfonso and Ben-Ari, Yehezkel and Khazipov, Rustem}, year={2006}, month=dec, pages={1788–1792} }

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