DOI: 10.1126/science.1119426. Ambient Mass Spectrometry

10.1126/science.1119426

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or preseparation by creating ions outside the instrument. In desorption electrospray ionization (DESI), the principal method described here, electrically charged droplets are directed at the ambient object of interest; they release ions from the surface, which are then vacuumed through the air into a conventional mass spectrometer. Extremely rapid analysis is coupled with high sensitivity and high chemical specificity. These characteristics are advantageously applied to high-throughput metabolomics, explosives detection, natural products discovery, and biological tissue imaging, among other applications. Future possible uses of DESI for in vivo clinical analysis and its adaptation to portable mass spectrometers are described.

Bibliography

Cooks, R. G., Ouyang, Z., Takats, Z., & Wiseman, J. M. (2006). Ambient Mass Spectrometry. Science, 311(5767), 1566â1570.

Authors 4

R. Graham Cooks (first)
Zheng Ouyang (additional)
Zoltan Takats (additional)
Justin M. Wiseman (additional)

References 37 Referenced 1,318

10.1126/science.2675315
10.1021/cr00079a009
10.1021/ac00171a028
10.1021/ac990998k
10.1126/science.1104404
10.1021/cr980137w
10.1002/rcm.1290051004
10.1021/ac050162j
Z. Takats, I. Cotte-Rodriguez, N. Talaty, H. W. Chen, R. G. Cooks, Chem. Commun.1950 (2005). / Chem. Commun. (2005)
10.1002/rcm.2243
10.1021/ac051470k
10.1021/ac050995
10.1002/jms.922
M. Nefliu, A. Venter, R. G. Cooks, Chem. Commun.,888 (2006). / Chem. Commun., (2006)
10.1002/oms.1210230506
10.1002/1096-9888(200007)35:7<804::AID-JMS22>3.0.CO;2-Q
10.1021/ac050989d
S. Rodriguez-Cruz, Rapid Commun. Mass Spectrom.20, 53 (2005). / Rapid Commun. Mass Spectrom. (2005)
10.1021/ac051277q
10.1002/rcm.2251
K. A. Hall M. Green P. Newton F. Fernandez paper presented at the 53rd American Society for Mass Spectrometry San Antonio TX June 5–9 2005.
J. Henion C. Van Pelt T. Corso G. Schultz X. Huang paper presented at the 53rd American Society for Mass Spectrometry San Antonio TX 2005.
10.1002/rcm.2280
10.1021/ac048217p
10.1039/b511161g
H. Chen Z. Pan N. Talaty R. G. Cooks D. Raftery Rapid Commun. Mass Spectrom. in press.
10.1021/ac970888i
10.1002/jms.735
10.1016/j.jasms.2005.06.005
10.1002/jms.153
10.1002/anie.200502362
M. Nefliu C. Moore R. G. Cooks in preparation.
H. Chen I. Cotte-Rodriguez R. G. Cooks Chem. Commun. in press.
10.1002/(SICI)1098-2787(1997)16:1<1::AID-MAS1>3.0.CO;2-L
10.1126/science.1120177
L. Gao Q. Song R. G. Cooks Z. Ouyang in preparation.
This work was supported by grants from NSF the Office of Naval Research and Prosolia Inc. (through the Indiana 21st Century Fund). We acknowledge the contributions of collaborators cited in the references.

Dates

Type	When
Created	19 years, 5 months ago (March 16, 2006, 4:58 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:01 p.m.)
Indexed	3 days, 7 hours ago (Sept. 4, 2025, 10:05 a.m.)
Issued	19 years, 5 months ago (March 17, 2006)
Published	19 years, 5 months ago (March 17, 2006)
Published Print	19 years, 5 months ago (March 17, 2006)

Funders 0

None

BibTeX

@article{Cooks_2006, title={Ambient Mass Spectrometry}, volume={311}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1119426}, DOI={10.1126/science.1119426}, number={5767}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cooks, R. Graham and Ouyang, Zheng and Takats, Zoltan and Wiseman, Justin M.}, year={2006}, month=mar, pages={1566–1570} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T14:05:26Z",
    "timestamp": 1756994726063
  },
  "reference-count": 37,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "5767",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        3,
        17
      ]
    ]
  },
  "abstract": "<jats:p>A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or preseparation by creating ions outside the instrument. In desorption electrospray ionization (DESI), the principal method described here, electrically charged droplets are directed at the ambient object of interest; they release ions from the surface, which are then vacuumed through the air into a conventional mass spectrometer. Extremely rapid analysis is coupled with high sensitivity and high chemical specificity. These characteristics are advantageously applied to high-throughput metabolomics, explosives detection, natural products discovery, and biological tissue imaging, among other applications. Future possible uses of DESI for in vivo clinical analysis and its adaptation to portable mass spectrometers are described.</jats:p>",
  "DOI": "10.1126/science.1119426",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        3,
        16
      ]
    ],
    "date-time": "2006-03-16T21:58:06Z",
    "timestamp": 1142546286000
  },
  "page": "1566-1570",
  "source": "Crossref",
  "is-referenced-by-count": 1318,
  "title": "Ambient Mass Spectrometry",
  "prefix": "10.1126",
  "volume": "311",
  "author": [
    {
      "given": "R. Graham",
      "family": "Cooks",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA."
        },
        {
          "name": "Institute of Structural Chemistry, Chemical Research Centre of the Hungarian Academy of Sciences, Pusztaszeri ut 59-67, Budapest, Hungary."
        }
      ]
    },
    {
      "given": "Zheng",
      "family": "Ouyang",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA."
        },
        {
          "name": "Institute of Structural Chemistry, Chemical Research Centre of the Hungarian Academy of Sciences, Pusztaszeri ut 59-67, Budapest, Hungary."
        }
      ]
    },
    {
      "given": "Zoltan",
      "family": "Takats",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA."
        },
        {
          "name": "Institute of Structural Chemistry, Chemical Research Centre of the Hungarian Academy of Sciences, Pusztaszeri ut 59-67, Budapest, Hungary."
        }
      ]
    },
    {
      "given": "Justin M.",
      "family": "Wiseman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA."
        },
        {
          "name": "Institute of Structural Chemistry, Chemical Research Centre of the Hungarian Academy of Sciences, Pusztaszeri ut 59-67, Budapest, Hungary."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_3_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2675315"
    },
    {
      "key": "e_1_3_1_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cr00079a009"
    },
    {
      "key": "e_1_3_1_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac00171a028"
    },
    {
      "key": "e_1_3_1_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac990998k"
    },
    {
      "key": "e_1_3_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1104404"
    },
    {
      "key": "e_1_3_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cr980137w"
    },
    {
      "key": "e_1_3_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/rcm.1290051004"
    },
    {
      "key": "e_1_3_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac050162j"
    },
    {
      "key": "e_1_3_1_10_2",
      "first-page": "1950",
      "year": "2005",
      "unstructured": "Z. Takats, I. Cotte-Rodriguez, N. Talaty, H. W. Chen, R. G. Cooks, Chem. Commun.1950 (2005).",
      "journal-title": "Chem. Commun."
    },
    {
      "key": "e_1_3_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/rcm.2243"
    },
    {
      "key": "e_1_3_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac051470k"
    },
    {
      "key": "e_1_3_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac050995"
    },
    {
      "key": "e_1_3_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jms.922"
    },
    {
      "key": "e_1_3_1_15_2",
      "first-page": "888",
      "year": "2006",
      "unstructured": "M. Nefliu, A. Venter, R. G. Cooks, Chem. Commun.,888 (2006).",
      "journal-title": "Chem. Commun.,"
    },
    {
      "key": "e_1_3_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/oms.1210230506"
    },
    {
      "key": "e_1_3_1_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/1096-9888(200007)35:7<804::AID-JMS22>3.0.CO;2-Q"
    },
    {
      "key": "e_1_3_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac050989d"
    },
    {
      "key": "e_1_3_1_19_2",
      "first-page": "53",
      "volume": "20",
      "year": "2005",
      "unstructured": "S. Rodriguez-Cruz, Rapid Commun. Mass Spectrom.20, 53 (2005).",
      "journal-title": "Rapid Commun. Mass Spectrom."
    },
    {
      "key": "e_1_3_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac051277q"
    },
    {
      "key": "e_1_3_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/rcm.2251"
    },
    {
      "key": "e_1_3_1_22_2",
      "unstructured": "K. A. Hall M. Green P. Newton F. Fernandez paper presented at the 53rd American Society for Mass Spectrometry San Antonio TX June 5\u20139 2005."
    },
    {
      "key": "e_1_3_1_23_2",
      "unstructured": "J. Henion C. Van Pelt T. Corso G. Schultz X. Huang paper presented at the 53rd American Society for Mass Spectrometry San Antonio TX 2005."
    },
    {
      "key": "e_1_3_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/rcm.2280"
    },
    {
      "key": "e_1_3_1_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac048217p"
    },
    {
      "key": "e_1_3_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/b511161g"
    },
    {
      "key": "e_1_3_1_27_2",
      "unstructured": "H. Chen Z. Pan N. Talaty R. G. Cooks D. Raftery Rapid Commun. Mass Spectrom. in press."
    },
    {
      "key": "e_1_3_1_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ac970888i"
    },
    {
      "key": "e_1_3_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jms.735"
    },
    {
      "key": "e_1_3_1_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jasms.2005.06.005"
    },
    {
      "key": "e_1_3_1_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jms.153"
    },
    {
      "key": "e_1_3_1_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.200502362"
    },
    {
      "key": "e_1_3_1_33_2",
      "unstructured": "M. Nefliu C. Moore R. G. Cooks in preparation."
    },
    {
      "key": "e_1_3_1_34_2",
      "unstructured": "H. Chen I. Cotte-Rodriguez R. G. Cooks Chem. Commun. in press."
    },
    {
      "key": "e_1_3_1_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1098-2787(1997)16:1<1::AID-MAS1>3.0.CO;2-L"
    },
    {
      "key": "e_1_3_1_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1120177"
    },
    {
      "key": "e_1_3_1_37_2",
      "unstructured": "L. Gao Q. Song R. G. Cooks Z. Ouyang in preparation."
    },
    {
      "key": "e_1_3_1_38_2",
      "unstructured": "This work was supported by grants from NSF the Office of Naval Research and Prosolia Inc. (through the Indiana 21st Century Fund). We acknowledge the contributions of collaborators cited in the references."
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.1119426",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        10
      ]
    ],
    "date-time": "2024-01-10T02:01:31Z",
    "timestamp": 1704852091000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.1119426"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        3,
        17
      ]
    ]
  },
  "references-count": 37,
  "journal-issue": {
    "issue": "5767",
    "published-print": {
      "date-parts": [
        [
          2006,
          3,
          17
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.1119426"
  ],
  "URL": "http://dx.doi.org/10.1126/science.1119426",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        2006,
        3,
        17
      ]
    ]
  }
}