DOI: 10.1126/science.1118642. Integration of Plant Responses to Environmentally Activated Phytohormonal Signals

Integration of Plant Responses to Environmentally Activated Phytohormonal Signals

10.1126/science.1118642

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Plants live in fixed locations and survive adversity by integrating growth responses to diverse environmental signals. Here, we show that the nuclear-localized growth-repressing DELLA proteins of Arabidopsis integrate responses to independent hormonal and environmental signals of adverse conditions. The growth restraint conferred by DELLA proteins is beneficial and promotes survival. We propose that DELLAs permit flexible and appropriate modulation of plant growth in response to changes in natural environments.

Bibliography

Achard, P., Cheng, H., De Grauwe, L., Decat, J., Schoutteten, H., Moritz, T., Van Der Straeten, D., Peng, J., & Harberd, N. P. (2006). Integration of Plant Responses to Environmentally Activated Phytohormonal Signals. Science, 311(5757), 91â94.

Authors 9

Patrick Achard (first)
Hui Cheng (additional)
Liesbeth De Grauwe (additional)
Jan Decat (additional)
Hermien Schoutteten (additional)
Thomas Moritz (additional)
Dominique Van Der Straeten (additional)
Jinrong Peng (additional)
Nicholas P. Harberd (additional)

References 31 Referenced 1,236

10.1016/j.pbi.2004.11.015
10.1101/gad.11.23.3194
10.1038/22307
10.1126/science.1083217
10.1105/tpc.021386
10.1038/nature01387
10.1105/tpc.015685
10.1046/j.1365-313X.2003.01975.x
10.1146/annurev.arplant.53.091401.143329
10.1126/science.285.5431.1256
10.1242/dev.00992
P. Achard et al. data not shown.
10.1093/genetics/159.2.767
A. L. Silverstoneet al., Plant Cell13, 1555 (2001). / Plant Cell (2001)
10.1111/j.1365-313X.2003.01998.x
10.1016/S1369-5266(03)00092-X
J. Leung, S. Merlot, J. Giraudat, Plant Cell9, 759 (1997). / Plant Cell (1997)
10.1105/tpc.11.10.1897
10.1126/science.296.5566.285
10.1242/dev.01206
Materials and Methods are available as supporting online material on Science Online.
10.1242/dev.124.19.3835
10.1105/tpc.10.5.791
10.1038/35009125
10.1105/tpc.001768
10.1104/pp.108.2.597
S. Y. Fujimoto, M. Ohta, A. Usui, H. Shinshi, M. Ohme-Takagi, Plant Cell12, 393 (2000). / Plant Cell (2000)
10.1016/S0092-8674(03)00969-3
10.1016/S0092-8674(03)00968-1
10.1073/pnas.0401698101
We thank T. Sun for pRGA:GFP-RGA C. Lloyd for the antibody to β-tubulin P. Genschik and J. Leung for mutant Arabidopsis lines and I. Carlson for assistance with the GA analyses. We gratefully acknowledge funding from the European Union (RTN1-2000-00090 INTEGA) and the Biotechnology and Biological Sciences Research Council (Core Strategic Grant to the John Innes Centre and response modes grant 208/P19972) the Belgian Science Policy Office Fund for Scientific Research (Flanders) and Ghent University. We thank L. Alvey C. Dean X. Fu J. Jones L. Navarro D. Richards H. Sakai A. Smith and Y. Yasumura for comments on the manuscript and L. Sakvarelidze for computing assistance during the creation of the figures.

Dates

Type	When
Created	19 years, 7 months ago (Jan. 5, 2006, 6:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:19 p.m.)
Indexed	13 hours, 6 minutes ago (Sept. 3, 2025, 7:17 a.m.)
Issued	19 years, 7 months ago (Jan. 6, 2006)
Published	19 years, 7 months ago (Jan. 6, 2006)
Published Print	19 years, 7 months ago (Jan. 6, 2006)

Funders 0

None

BibTeX

@article{Achard_2006, title={Integration of Plant Responses to Environmentally Activated Phytohormonal Signals}, volume={311}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1118642}, DOI={10.1126/science.1118642}, number={5757}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Achard, Patrick and Cheng, Hui and De Grauwe, Liesbeth and Decat, Jan and Schoutteten, Hermien and Moritz, Thomas and Van Der Straeten, Dominique and Peng, Jinrong and Harberd, Nicholas P.}, year={2006}, month=jan, pages={91–94} }

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