DOI: 10.1126/science.1114021. The Ins and Outs of DNA Transfer in Bacteria

The Ins and Outs of DNA Transfer in Bacteria

10.1126/science.1114021

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Transformation and conjugation permit the passage of DNA through the bacterial membranes and represent dominant modes for the transfer of genetic information between bacterial cells or between bacterial and eukaryotic cells. As such, they are responsible for the spread of fitness-enhancing traits, including antibiotic resistance. Both processes usually involve the recognition of double-stranded DNA, followed by the transfer of single strands. Elaborate molecular machines are responsible for negotiating the passage of macromolecular DNA through the layers of the cell surface. All or nearly all the machine components involved in transformation and conjugation have been identified, and here we present models for their roles in DNA transport.

Bibliography

Chen, I., Christie, P. J., & Dubnau, D. (2005). The Ins and Outs of DNA Transfer in Bacteria. Science, 310(5753), 1456â1460.

Authors 3

Inês Chen (first)
Peter J. Christie (additional)
David Dubnau (additional)

References 81 Referenced 369

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Work in the Christie laboratory is supported by NIH grant GM48746 and in the Dubnau lab by GM057720 and GM43756. We apologize for the omission of many primary references because of space limitations.

Dates

Type	When
Created	19 years, 9 months ago (Dec. 1, 2005, 6:16 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:22 p.m.)
Indexed	4 days, 1 hour ago (Aug. 29, 2025, 5:58 a.m.)
Issued	19 years, 9 months ago (Dec. 2, 2005)
Published	19 years, 9 months ago (Dec. 2, 2005)
Published Print	19 years, 9 months ago (Dec. 2, 2005)

Funders 0

None

BibTeX

@article{Chen_2005, title={The Ins and Outs of DNA Transfer in Bacteria}, volume={310}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1114021}, DOI={10.1126/science.1114021}, number={5753}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Chen, Inês and Christie, Peter J. and Dubnau, David}, year={2005}, month=dec, pages={1456–1460} }

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