DOI: 10.1126/science.1113666. Principles of Selective Ion Transport in Channels and Pumps

Principles of Selective Ion Transport in Channels and Pumps

10.1126/science.1113666

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The transport of ions across the membranes of cells and organelles is a prerequisite for many of life's processes. Transport often involves very precise selectivity for specific ions. Recently, atomic-resolution structures have been determined for channels or pumps that are selective for sodium, potassium, calcium, and chloride: four of the most abundant ions in biology. From these structures we can begin to understand the principles of selective ion transport in terms of the architecture and detailed chemistry of the ion conduction pathways.

Bibliography

Gouaux, E., & MacKinnon, R. (2005). Principles of Selective Ion Transport in Channels and Pumps. Science, 310(5753), 1461â1465.

Authors 2

Eric Gouaux (first)
Roderick MacKinnon (additional)

References 28 Referenced 900

B. Hille Ion Channels of Excitable Membranes (Sinauer Sunderland MA ed. 3 2001).
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10.1038/415287a
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10.1016/j.sbi.2005.06.005
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J. D. Dunitz, M. Dobler, in Biological Aspects of Inorganic Chemistry, A. W. Addison, W. R. Cullen, D. Dolphin, B. R. James, Eds. (Wiley, New York, 1977), pp. 113–140. / Biological Aspects of Inorganic Chemistry (1977)
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Research in the authors' laboratories is supported by NIH and the Howard Hughes Medical Institute.

Dates

Type	When
Created	19 years, 8 months ago (Dec. 1, 2005, 6:16 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:22 p.m.)
Indexed	19 minutes ago (Aug. 21, 2025, 1:04 p.m.)
Issued	19 years, 8 months ago (Dec. 2, 2005)
Published	19 years, 8 months ago (Dec. 2, 2005)
Published Print	19 years, 8 months ago (Dec. 2, 2005)

Funders 0

None

BibTeX

@article{Gouaux_2005, title={Principles of Selective Ion Transport in Channels and Pumps}, volume={310}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1113666}, DOI={10.1126/science.1113666}, number={5753}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Gouaux, Eric and MacKinnon, Roderick}, year={2005}, month=dec, pages={1461–1465} }

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