DOI: 10.1126/science.1112160. Progress in Modeling of Protein Structures and Interactions

Progress in Modeling of Protein Structures and Interactions

10.1126/science.1112160

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.

Bibliography

Schueler-Furman, O., Wang, C., Bradley, P., Misura, K., & Baker, D. (2005). Progress in Modeling of Protein Structures and Interactions. Science, 310(5748), 638â642.

Authors 5

Ora Schueler-Furman (first)
Chu Wang (additional)
Phil Bradley (additional)
Kira Misura (additional)
David Baker (additional)

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The software used in the prediction and design examples described above is available free for academic use in the ROSETTA software package (http://depts.washington.edu/ventures/UW_Technology/Express_Licenses/Rosetta/) and personal computers can be enlisted in the conformational sampling essential to the prediction effort at http://boinc.bakerlab.org/rosetta/.

Dates

Type	When
Created	19 years, 10 months ago (Oct. 27, 2005, 6:38 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 8:53 p.m.)
Indexed	3 months, 3 weeks ago (May 15, 2025, 12:11 a.m.)
Issued	19 years, 10 months ago (Oct. 28, 2005)
Published	19 years, 10 months ago (Oct. 28, 2005)
Published Print	19 years, 10 months ago (Oct. 28, 2005)

Funders 0

None

BibTeX

@article{Schueler_Furman_2005, title={Progress in Modeling of Protein Structures and Interactions}, volume={310}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1112160}, DOI={10.1126/science.1112160}, number={5748}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schueler-Furman, Ora and Wang, Chu and Bradley, Phil and Misura, Kira and Baker, David}, year={2005}, month=oct, pages={638–642} }

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