DOI: 10.1126/science.1107679. Bacterial Injectisomes: Needle Length Does Matter

Bacterial Injectisomes: Needle Length Does Matter

10.1126/science.1107679

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Many pathogenic bacteria use a type III secretion nanomachine (an injectisome) to deliver virulence proteins into the cytosol of their eukaryotic host cells. Most injectisomes possess a stiff needlelike structure of a genetically defined length. We found that a minimal needle length was required for efficient functioning of the Yersinia enterocolitica injectisome. This minimal needle length correlated with the length of the major adhesin at the bacterial surface. The needle may be required for triggering type III secretion, and its length may have evolved to match specific structures at the bacterial and host cell surfaces.

Bibliography

Mota, L. J., Journet, L., Sorg, I., Agrain, C., & Cornelis, G. R. (2005). Bacterial Injectisomes: Needle Length Does Matter. Science, 307(5713), 1278â1278.

Authors 5

Luís Jaime Mota (first)
Laure Journet (additional)
Isabel Sorg (additional)
Céline Agrain (additional)
Guy R. Cornelis (additional)

References 7 Referenced 104

10.1126/science.284.5418.1322
10.1126/science.1102610
10.1126/science.1091422
10.1038/nrm932
10.1093/emboj/19.22.5989
10.1126/science.286.5438.291
We thank M. Dürrenberger G. Morson and U. M. Spornitz for use of electron microscope facilities; J. A. Bengoechea and U. Jenal for discussions; K. T. Hughes and J. Pieters for critical reading; and the Swiss National Science Foundation for grant no. 32-65393.01.

Dates

Type	When
Created	20 years, 5 months ago (Feb. 24, 2005, 4 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:29 p.m.)
Indexed	3 months, 3 weeks ago (May 1, 2025, 1:44 p.m.)
Issued	20 years, 5 months ago (Feb. 25, 2005)
Published	20 years, 5 months ago (Feb. 25, 2005)
Published Print	20 years, 5 months ago (Feb. 25, 2005)

Funders 0

None

BibTeX

@article{Mota_2005, title={Bacterial Injectisomes: Needle Length Does Matter}, volume={307}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1107679}, DOI={10.1126/science.1107679}, number={5713}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Mota, Luís Jaime and Journet, Laure and Sorg, Isabel and Agrain, Céline and Cornelis, Guy R.}, year={2005}, month=feb, pages={1278–1278} }

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