DOI: 10.1126/science.1107470. Control of Excitatory and Inhibitory Synapse Formation by Neuroligins

Control of Excitatory and Inhibitory Synapse Formation by Neuroligins

10.1126/science.1107470

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.

Bibliography

Chih, B., Engelman, H., & Scheiffele, P. (2005). Control of Excitatory and Inhibitory Synapse Formation by Neuroligins. Science, 307(5713), 1324â1328.

Authors 3

Ben Chih (first)
Holly Engelman (additional)
Peter Scheiffele (additional)

References 29 Referenced 585

10.1016/S0092-8674(00)80877-6
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Materials and methods are available as supporting material on Science Online.
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We thank T. Jessell and A. Eickhorst for comments on the manuscript L. van Parijs for vector DNA A. MacDermott and G. Crabtree for generously sharing equipment C. Torsney for help with statistical analysis M. Peck for help with quantifications and J. Dodd for continuous support. This work was financially supported by the Irma T. Hirschl Fund the Searle Scholar Program the John Merck Fund and National Institute of Neurological Disorders and Stroke.

Dates

Type	When
Created	20 years, 7 months ago (Jan. 27, 2005, 8:34 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:27 p.m.)
Indexed	20 minutes ago (Aug. 30, 2025, 2:23 a.m.)
Issued	20 years, 6 months ago (Feb. 25, 2005)
Published	20 years, 6 months ago (Feb. 25, 2005)
Published Print	20 years, 6 months ago (Feb. 25, 2005)

Funders 0

None

BibTeX

@article{Chih_2005, title={Control of Excitatory and Inhibitory Synapse Formation by Neuroligins}, volume={307}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1107470}, DOI={10.1126/science.1107470}, number={5713}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Chih, Ben and Engelman, Holly and Scheiffele, Peter}, year={2005}, month=feb, pages={1324–1328} }

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