DOI: 10.1126/science.1105322. Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees

Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees

10.1126/science.1105322

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite ∼99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.

Bibliography

Winckler, W., Myers, S. R., Richter, D. J., Onofrio, R. C., McDonald, G. J., Bontrop, R. E., McVean, G. A. T., Gabriel, S. B., Reich, D., Donnelly, P., & Altshuler, D. (2005). Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees. Science, 308(5718), 107â111.

Authors 11

Wendy Winckler (first)
Simon R. Myers (additional)
Daniel J. Richter (additional)
Robert C. Onofrio (additional)
Gavin J. McDonald (additional)
Ronald E. Bontrop (additional)
Gilean A. T. McVean (additional)
Stacey B. Gabriel (additional)
David Reich (additional)
Peter Donnelly (additional)
David Altshuler (additional)

References 27 Referenced 308

10.1073/pnas.97.21.11383
10.1126/science.1092500
10.1038/ng1376
A. Chakravarti et al., Am. J. Hum. Genet.36, 1239 (1984). / Am. J. Hum. Genet. (1984)
10.1093/hmg/9.5.725
10.1038/ng1001-217
10.1126/science.8290959
10.1002/j.1460-2075.1991.tb07750.x
10.1038/ng910
10.1093/emboj/cdg136
10.1038/338035a0
10.1073/pnas.94.15.8058
Materials and methods are available as supporting material on Science Online.
10.1093/bioinformatics/bth457
10.1182/blood.V92.11.4415
10.1093/hmg/11.3.207
10.1371/journal.pbio.0020155
10.1086/380311
We note that the previous study ( 18 ) that did not find evidence for a hotspot in the chimpanzee β-globin region did not examine the adjacent region in which we found an elevated rate of recombination in the chimpanzee.
www.hapmap.org/.
10.1126/science.1069424
10.1086/340787
10.1038/nature02564
10.1093/genetics/164.4.1567
10.1093/genetics/163.1.375
10.1038/10297
We thank the members of the Altshuler Daly and Donnelly laboratories and the participants in the International Haplotype Map Project for helpful discussions. D.A. is a Charles E. Culpeper Scholar of the Rockefeller Brothers Fund and a Burroughs Wellcome Fund clinical scholar in translational research. P.D. is supported by NIH Wellcome Trust Nuffield Trust the SNP Consortium and Wolfson Foundation. G.A.T.M. is supported by NIH The Royal Society and the SNP Consortium. D.R. is the recipient of a Career Development Award in Biomedical Science from the Burroughs Wellcome Fund.

Dates

Type	When
Created	20 years, 6 months ago (Feb. 10, 2005, 8:33 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:02 p.m.)
Indexed	1 month ago (Aug. 3, 2025, 6:49 p.m.)
Issued	20 years, 5 months ago (April 1, 2005)
Published	20 years, 5 months ago (April 1, 2005)
Published Print	20 years, 5 months ago (April 1, 2005)

Funders 0

None

BibTeX

@article{Winckler_2005, title={Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees}, volume={308}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1105322}, DOI={10.1126/science.1105322}, number={5718}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Winckler, Wendy and Myers, Simon R. and Richter, Daniel J. and Onofrio, Robert C. and McDonald, Gavin J. and Bontrop, Ronald E. and McVean, Gilean A. T. and Gabriel, Stacey B. and Reich, David and Donnelly, Peter and Altshuler, David}, year={2005}, month=apr, pages={107–111} }

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