DOI: 10.1126/science.1100815. Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses

Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses

10.1126/science.1100815

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The efficacy and short-term modification of neocortical synaptic connections vary with the type of target neuron. We investigated presynaptic Ca 2+ and release probability at single synaptic contacts between pairs of neurons in layer 2/3 of the rat neocortex. The amplitude of Ca 2+ signals in boutons of pyramids contacting bitufted or multipolar interneurons or other pyramids was dependent on the target cell type. Optical quantal analysis at single synaptic contacts suggested that release probabilities are also target cell-specific. Both the Ca 2+ signal and the release probability of different boutons of a pyramid contacting the same target cell varied little. We propose that the mechanisms that regulate the functional properties of boutons of a pyramid normalize the presynaptic Ca 2+ influx and release probability for all those boutons that innervate the same target cell.

Bibliography

Koester, H. J., & Johnston, D. (2005). Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses. Science, 308(5723), 863â866.

Authors 2

Helmut J. Koester (first)
Daniel Johnston (additional)

References 30 Referenced 187

10.1152/jn.1998.79.3.1219
10.1006/nlme.1998.3841
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L. F. Abbott, J. A. Varela, K. Sen, S. B. Nelson, Science275, 220 (1997). / Science (1997)
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We thank B. Sakmann for his support during the early stages of this project and for critically reading the manuscript. Supported by the European Union and by NIH grant nos. NNS37444 MH48432 and MH44754.

Dates

Type	When
Created	20 years, 5 months ago (March 17, 2005, 11:55 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:09 p.m.)
Indexed	1 month, 3 weeks ago (July 6, 2025, 10:05 a.m.)
Issued	20 years, 3 months ago (May 6, 2005)
Published	20 years, 3 months ago (May 6, 2005)
Published Print	20 years, 3 months ago (May 6, 2005)

Funders 0

None

BibTeX

@article{Koester_2005, title={Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses}, volume={308}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1100815}, DOI={10.1126/science.1100815}, number={5723}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Koester, Helmut J. and Johnston, Daniel}, year={2005}, month=may, pages={863–866} }

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