DOI: 10.1126/science.1096645. Regulation of an <i>ATG7</i> - <i>beclin 1</i> Program of Autophagic Cell Death by Caspase-8

Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

10.1126/science.1096645

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy. Autophagic death required the genes ATG7 and beclin 1 and was induced by caspase-8 inhibition. Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death.

Bibliography

Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E. H., & Lenardo, M. J. (2004). Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8. Science, 304(5676), 1500â1502.

Authors 8

Li Yu (first)
Ajjai Alva (additional)
Helen Su (additional)
Parmesh Dutt (additional)
Eric Freundt (additional)
Sarah Welsh (additional)
Eric H. Baehrecke (additional)
Michael J. Lenardo (additional)

References 29 Referenced 996

10.1016/0959-437X(94)90076-F
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M. Leist, M. Jaattela, Nature Rev. Mol. Cell Biol.2, 589 (2001). / Nature Rev. Mol. Cell Biol. (2001)
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The authors thank T. Maugel for assistance with TEM and R. Siegel J. Puck L. Zheng S. Straus and D. Douek for comments on the manuscript. E.F. is an NIH–Oxford University Scholar in Biomedical Research. H.S. is a Fellow of Cancer Research Institute. This work was supported by NIH grant GM59136 (E.H.B.).

Dates

Type	When
Created	21 years, 3 months ago (May 10, 2004, 8:44 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 8:55 p.m.)
Indexed	1 week, 2 days ago (Aug. 23, 2025, 1 a.m.)
Issued	21 years, 2 months ago (June 4, 2004)
Published	21 years, 2 months ago (June 4, 2004)
Published Print	21 years, 2 months ago (June 4, 2004)

Funders 0

None

BibTeX

@article{Yu_2004, title={Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8}, volume={304}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1096645}, DOI={10.1126/science.1096645}, number={5676}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yu, Li and Alva, Ajjai and Su, Helen and Dutt, Parmesh and Freundt, Eric and Welsh, Sarah and Baehrecke, Eric H. and Lenardo, Michael J.}, year={2004}, month=jun, pages={1500–1502} }

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