DOI: 10.1126/science.1096330. Illuminating the Evolutionary History of Chlamydiae

Illuminating the Evolutionary History of Chlamydiae

10.1126/science.1096330

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.

Bibliography

Horn, M., Collingro, A., Schmitz-Esser, S., Beier, C. L., Purkhold, U., Fartmann, B., Brandt, P., Nyakatura, G. J., Droege, M., Frishman, D., Rattei, T., Mewes, H.-W., & Wagner, M. (2004). Illuminating the Evolutionary History of Chlamydiae. Science, 304(5671), 728â730.

Authors 13

Matthias Horn (first)
Astrid Collingro (additional)
Stephan Schmitz-Esser (additional)
Cora L. Beier (additional)
Ulrike Purkhold (additional)
Berthold Fartmann (additional)
Petra Brandt (additional)
Gerald J. Nyakatura (additional)
Marcus Droege (additional)
Dmitrij Frishman (additional)
Thomas Rattei (additional)
Hans-Werner Mewes (additional)
Michael Wagner (additional)

References 29 Referenced 337

J. Schachter, in Chlamydia, R. S. Stephens, Ed. (American Society for Microbiology, Washington, DC, 1999), pp. 139–169. / Chlamydia (1999)
10.1128/jb.167.2.570-574.1986
10.1099/00207713-49-2-415
10.1128/aem.63.1.115-121.1997
10.1128/AEM.66.6.2613-2619.2000
10.1099/00221287-146-5-1231
10.1099/13500872-145-2-411
10.1111/j.1574-6968.2001.tb10865.x
M. E. Ward www.chlamydiae.com.
Materials and methods are available as supporting material on Science Online. The genome sequence has been deposited at EMBL/GenBank/DDBJ (accession no. BX908798). A comprehensive genome database is available at http://mips.gsf.de/services/genomes/uwe25.
10.1126/science.282.5389.754
10.1038/7716
10.1093/nar/28.6.1397
10.1093/nar/28.12.2311
10.1093/nar/gkg321
10.1126/science.1058543
10.1128/AEM.66.4.1328-1333.2000
10.1101/gr.341802
G. McClarty, in Chlamydia, R. S. Stephens, Ed. (American Society for Microbiology, Washington, DC, 1999), pp. 69–100. / Chlamydia (1999)
R. S. Stephens, in Chlamydia, R. S. Stephens, Ed. (American Society for Microbiology, Washington, DC, 1999), pp. 9–27. / Chlamydia (1999)
10.1128/JB.186.3.683-691.2004
10.1128/JB.181.4.1196-1202.1999
T. P. Hatch, in Chlamydia, R. S. Stephens, Ed. (American Society for Microbiology, Washington, DC, 1999), pp. 29–67. / Chlamydia (1999)
10.1128/MMBR.62.2.379-433.1998
10.1016/S0966-842X(00)01792-3
10.1007/PL00006158
10.1084/jem.193.8.935
10.1128/IAI.71.10.5979-5985.2003
We thank T. R. Fritsche for arousing our interest in bacterial symbionts of amoebae; W. Goebel K.-H. Schleifer A. Leeb and H. Daims for their support; and M. E. Ward and I. M. Head for critical reading of the manuscript. This work was funded by the bmb+f PathoGenomiK network (grant PTJ-BIO/03U213B).

Dates

Type	When
Created	21 years, 4 months ago (April 12, 2004, 8:43 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 10:34 p.m.)
Indexed	4 weeks ago (Aug. 3, 2025, 7:05 p.m.)
Issued	21 years, 4 months ago (April 30, 2004)
Published	21 years, 4 months ago (April 30, 2004)
Published Print	21 years, 4 months ago (April 30, 2004)

Funders 0

None

BibTeX

@article{Horn_2004, title={Illuminating the Evolutionary History of Chlamydiae}, volume={304}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1096330}, DOI={10.1126/science.1096330}, number={5671}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Horn, Matthias and Collingro, Astrid and Schmitz-Esser, Stephan and Beier, Cora L. and Purkhold, Ulrike and Fartmann, Berthold and Brandt, Petra and Nyakatura, Gerald J. and Droege, Marcus and Frishman, Dmitrij and Rattei, Thomas and Mewes, Hans-Werner and Wagner, Michael}, year={2004}, month=apr, pages={728–730} }

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