DOI: 10.1126/science.1087694. A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space

A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space

10.1126/science.1087694

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Transcriptional regulatory circuits provide only a fraction of the signaling pathways and regulatory mechanisms that control the bacterial cell cycle. The CtrA regulatory network, important in control of the Caulobacter cell cycle, illustrates the critical role of nontranscriptional pathways and temporally and spatially localized regulatory proteins. The system architecture of Caulobacter cell-cycle control involves top-down control of modular functions by a small number of master regulatory proteins with cross-module signaling coordinating the overall process. Modeling the cell cycle probably requires a top-down modeling approach and a hybrid control system modeling paradigm to treat its combined discrete and continuous characteristics.

Bibliography

McAdams, H. H., & Shapiro, L. (2003). A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space. Science, 301(5641), 1874â1877.

Authors 2

Harley H. McAdams (first)
Lucy Shapiro (additional)

References 36 Referenced 150

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H.H.M. is supported by Defense Advanced Research Projects Agency grant MDA972-00-1-0032 Department of Energy grant DE-FG03-01ER63219 and Office of Naval Research grant N00014-02-1-0538. L.S. is supported by National Institutes of Health grants GM32506/5120 M2 and GM51426.

Dates

Type	When
Created	21 years, 11 months ago (Sept. 25, 2003, 6:06 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 8:59 p.m.)
Indexed	1 month, 1 week ago (July 19, 2025, 11:52 p.m.)
Issued	21 years, 11 months ago (Sept. 26, 2003)
Published	21 years, 11 months ago (Sept. 26, 2003)
Published Print	21 years, 11 months ago (Sept. 26, 2003)

Funders 0

None

BibTeX

@article{McAdams_2003, title={A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space}, volume={301}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1087694}, DOI={10.1126/science.1087694}, number={5641}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={McAdams, Harley H. and Shapiro, Lucy}, year={2003}, month=sep, pages={1874–1877} }

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