DOI: 10.1126/science.1087576. Epidermal Viral Immunity Induced by CD8α <sup>+</sup> Dendritic Cells But Not by Langerhans Cells

Epidermal Viral Immunity Induced by CD8α + Dendritic Cells But Not by Langerhans Cells

10.1126/science.1087576

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8α + dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.

Bibliography

Allan, R. S., Smith, C. M., Belz, G. T., van Lint, A. L., Wakim, L. M., Heath, W. R., & Carbone, F. R. (2003). Epidermal Viral Immunity Induced by CD8Î± + Dendritic Cells But Not by Langerhans Cells. Science, 301(5641), 1925â1928.

Authors 7

Rhys S. Allan (first)
Chris M. Smith (additional)
Gabrielle T. Belz (additional)
Allison L. van Lint (additional)
Linda M. Wakim (additional)
William R. Heath (additional)
Francis R. Carbone (additional)

References 25 Referenced 464

D. Maurer G. Stingl in Dendritic Cells A. Thomson M. Lotze Eds. (Academic Press London 2001) vol. 2 chap. 5.
10.1084/jem.169.3.1169
M. Cumberbatch, I. Kimber, Immunology84, 31 (1995). / Immunology (1995)
10.1084/jem.181.6.2237
10.1016/0008-8749(76)90105-2
10.1084/jem.183.4.1287
10.1038/32588
10.1016/S0171-2985(82)80081-8
10.1111/j.1600-065X.1997.tb00956.x
10.1084/jem.166.6.1654
10.1038/nri746
10.4049/jimmunol.167.2.741
R. S. Allan C. M. Smith G. T. Belz W. R. Heath F. R. Carbone unpublished data.
10.1046/j.1440-1711.2002.01071.x
10.4049/jimmunol.170.9.4437
10.1084/jem.176.1.47
10.1084/jem.194.8.1171
10.1084/jem.20021031
10.1038/ni852
10.4049/jimmunol.168.2.834
10.1084/jem.20021109
10.1016/S1074-7613(00)80149-1
10.1002/eji.1830230730
10.1093/intimm/13.5.695
We are grateful for the assistance and advice of K. Shortman and the technical help of L. Coverdale S. Flynn G. Behrens and J.-L. Tan. Supported by grants from the National Health and Medical Research Council (Australia) Howard Hughes Medical Institute and the Wellcome Trust (UK).

Dates

Type	When
Created	21 years, 11 months ago (Sept. 25, 2003, 6:06 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 8:58 p.m.)
Indexed	6 days, 21 hours ago (Aug. 23, 2025, 8:51 p.m.)
Issued	21 years, 11 months ago (Sept. 26, 2003)
Published	21 years, 11 months ago (Sept. 26, 2003)
Published Print	21 years, 11 months ago (Sept. 26, 2003)

Funders 0

None

BibTeX

@article{Allan_2003, title={Epidermal Viral Immunity Induced by CD8α + Dendritic Cells But Not by Langerhans Cells}, volume={301}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1087576}, DOI={10.1126/science.1087576}, number={5641}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Allan, Rhys S. and Smith, Chris M. and Belz, Gabrielle T. and van Lint, Allison L. and Wakim, Linda M. and Heath, William R. and Carbone, Francis R.}, year={2003}, month=sep, pages={1925–1928} }

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