DOI: 10.1126/science.1086652. Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

10.1126/science.1086652

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Control of integrin affinity for ligands (integrin activation) is essential for normal cell adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually mediated through the integrin β subunit cytoplasmic tail and can be regulated by many different biochemical signaling pathways. We report that specific binding of the cytoskeletal protein talin to integrin β subunit cytoplasmic tails leads to the conformational rearrangements of integrin extracellular domains that increase their affinity. Thus, regulated binding of talin to integrin β tails is a final common element of cellular signaling cascades that control integrin activation.

Bibliography

Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., & Calderwood, D. A. (2003). Talin Binding to Integrin Ã Tails: A Final Common Step in Integrin Activation. Science, 302(5642), 103â106.

Authors 8

Seiji Tadokoro (first)
Sanford J. Shattil (additional)
Koji Eto (additional)
Vera Tai (additional)
Robert C. Liddington (additional)
José M. de Pereda (additional)
Mark H. Ginsberg (additional)
David A. Calderwood (additional)

References 26 Referenced 1,019

10.1038/385537a0
10.1016/0092-8674(95)90184-1
10.1016/S0092-8674(02)00971-6
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Materials and methods are available as supporting material on Science Online.
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10.1101/gad.981002
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P. Tapley, A. Horwitz, C. A. Buck, K. Duggan, L. Rohrschneider, Oncogene4, 325 (1989). / Oncogene (1989)
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10.1016/S0092-8674(02)00906-6
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Supported by grants from the NIH and American Heart Association.

Dates

Type	When
Created	21 years, 10 months ago (Oct. 2, 2003, 4:43 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 10:01 p.m.)
Indexed	1 day, 2 hours ago (Aug. 28, 2025, 8:55 a.m.)
Issued	21 years, 10 months ago (Oct. 3, 2003)
Published	21 years, 10 months ago (Oct. 3, 2003)
Published Print	21 years, 10 months ago (Oct. 3, 2003)

Funders 0

None

BibTeX

@article{Tadokoro_2003, title={Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation}, volume={302}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1086652}, DOI={10.1126/science.1086652}, number={5642}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Tadokoro, Seiji and Shattil, Sanford J. and Eto, Koji and Tai, Vera and Liddington, Robert C. and de Pereda, José M. and Ginsberg, Mark H. and Calderwood, David A.}, year={2003}, month=oct, pages={103–106} }

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