DOI: 10.1126/science.1085887. The Segmentation Clock: Converting Embryonic Time into Spatial Pattern

The Segmentation Clock: Converting Embryonic Time into Spatial Pattern

10.1126/science.1085887

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator—the segmentation clock— driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by fibroblast growth factor and Wnt signaling. This process converts the temporal oscillations into the periodic spatial pattern of somite boundaries. The study of somite development provides insights into the spatiotemporal integration of signaling systems in the vertebrate embryo.

Bibliography

PourquieÌ, O. (2003). The Segmentation Clock: Converting Embryonic Time into Spatial Pattern. Science, 301(5631), 328â330.

Authors 1

Olivier Pourquié (first)

References 27 Referenced 422

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The author thanks members of the Pourquié lab and P. Baumann K. Dale D. Duboule J. Dubrulle A. Gossler B. Hermann D. Ish-Horowicz R. Kageyama and P. Kulesa for helpful comments and discussions and for communicating data before their publication.

Dates

Type	When
Created	22 years, 1 month ago (July 17, 2003, 4:32 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:57 p.m.)
Indexed	1 day, 20 hours ago (Sept. 3, 2025, 7:08 a.m.)
Issued	22 years, 1 month ago (July 18, 2003)
Published	22 years, 1 month ago (July 18, 2003)
Published Print	22 years, 1 month ago (July 18, 2003)

Funders 0

None

BibTeX

@article{Pourquie__2003, title={The Segmentation Clock: Converting Embryonic Time into Spatial Pattern}, volume={301}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1085887}, DOI={10.1126/science.1085887}, number={5631}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pourquié, Olivier}, year={2003}, month=jul, pages={328–330} }

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