DOI: 10.1126/science.1085753. Organizing Axes in Time and Space; 25 Years of Colinear Tinkering

Organizing Axes in Time and Space; 25 Years of Colinear Tinkering

10.1126/science.1085753

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the “ Hox clock”). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our understanding of this enigmatic phenomenon, which may be caused by various and unrelated regulatory processes, as long as the final distribution of proteins (the HOX code) is preserved.

Bibliography

Kmita, M., & Duboule, D. (2003). Organizing Axes in Time and Space; 25 Years of Colinear Tinkering. Science, 301(5631), 331â333.

Authors 2

Marie Kmita (first)
Denis Duboule (additional)

References 38 Referenced 435

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We thank S. Cohen M. McDonald and J. Cobb for critical reading of the manuscript.

Dates

Type	When
Created	22 years, 1 month ago (July 17, 2003, 4:32 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:57 p.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 1:51 p.m.)
Issued	22 years, 1 month ago (July 18, 2003)
Published	22 years, 1 month ago (July 18, 2003)
Published Print	22 years, 1 month ago (July 18, 2003)

Funders 0

None

BibTeX

@article{Kmita_2003, title={Organizing Axes in Time and Space; 25 Years of Colinear Tinkering}, volume={301}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1085753}, DOI={10.1126/science.1085753}, number={5631}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kmita, Marie and Duboule, Denis}, year={2003}, month=jul, pages={331–333} }

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