DOI: 10.1126/science.1085259. Wnt Signaling, Ca <sup>2</sup> <sup>+</sup> , and Cyclic GMP: Visualizing Frizzled Functions

Wnt Signaling, Ca 2 + , and Cyclic GMP: Visualizing Frizzled Functions

10.1126/science.1085259

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Wnts control the specification of cell fate, cell adhesion, migration, polarity, and proliferation. Their roles in development have been probed in fruit flies, nematodes, zebrafish, frogs, and mice. Some Wnts inhibit the degradation of β-catenin, which can regulate transcription of specific genes. Other Wnts exert their influences in other ways, such as increasing intracellular concentrations of Ca 2 + and decreasing intracellular concentrations of cyclic guanosine monophosphate (cGMP). Heterotrimeric guanine nucleotide–binding proteins (G proteins) and RGS proteins have been implicated in Wnt signaling. Wnt regulation of intracellular Ca 2 + and cGMP levels requires the G protein transducin and a cGMP-specific phosphodiesterase, which are major elements in signaling of the visual pathway.

Bibliography

Wang, H., & Malbon, C. C. (2003). Wnt Signaling, Ca 2 + , and Cyclic GMP: Visualizing Frizzled Functions. Science, 300(5625), 1529â1530.

Authors 2

Hsien-yu Wang (first)
Craig C. Malbon (additional)

References 23 Referenced 113

10.1146/annurev.cellbio.14.1.59
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The authors acknowledge generous support from NIH and the March of Dimes Birth Defects Foundation.

Dates

Type	When
Created	22 years, 2 months ago (June 18, 2003, 4:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:40 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 7, 2025, 5:17 p.m.)
Issued	22 years, 2 months ago (June 6, 2003)
Published	22 years, 2 months ago (June 6, 2003)
Published Print	22 years, 2 months ago (June 6, 2003)

Funders 0

None

BibTeX

@article{Wang_2003, title={Wnt Signaling, Ca 2 + , and Cyclic GMP: Visualizing Frizzled Functions}, volume={300}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1085259}, DOI={10.1126/science.1085259}, number={5625}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wang, Hsien-yu and Malbon, Craig C.}, year={2003}, month=jun, pages={1529–1530} }

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