DOI: 10.1126/science.1084576. A Human Syndrome Caused by Immotile Cilia

A Human Syndrome Caused by Immotile Cilia

10.1126/science.1084576

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Four subjects who produced immotile sperm were studied. In three of the subjects, who had frequent bronchitis and sinusitis, there was no mucociliary transport, as measured by tracheobronchial clearance. Electron microscopy indicated that cilia from cells of these patients lack dynein arms.

Bibliography

Afzelius, B. A. (1976). A Human Syndrome Caused by Immotile Cilia. Science, 193(4250), 317â319.

Authors 1

Björn A. Afzelius (first)

References 36 Referenced 993

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AFZELIUS, B.A., JOURNAL OF CELL BIOLOGY 66: 225 (1975). (10.1083/jcb.66.2.225) / JOURNAL OF CELL BIOLOGY (1975)
AMJAD, H, KARTAGENER SYNDROME - CASE REPORT IN AN ELDERLY MAN, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 227: 1420 (1974). (10.1001/jama.1974.03230250044032) / JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (1974)
BERGSTROM, W.H., SITUS INVERSUS, BRONCHIECTASIS AND SINUSITIS - REPORT OF A FAMILY WITH 2 CASES OF KARTAGENERS TRIAD AND 2 ADDITIONAL CASES OF BRONCHIECTASIS AMONG 6 SIBLINGS, PEDIATRICS 6: 573 (1950). (10.1542/peds.6.4.573) / PEDIATRICS (1950)
CAMNER, P, EVIDENCE FOR CONGENITALLY NONFUNCTIONING CILIA IN TRACHEOBRONCHIAL TRACT IN 2 SUBJECTS, AMERICAN REVIEW OF RESPIRATORY DISEASE 112: 807 (1975). / AMERICAN REVIEW OF RESPIRATORY DISEASE (1975)
CAMNER, P, TRACHEOBRONCHIAL CLEARANCE AND CHRONIC OBSTRUCTIVE LUNG-DISEASE, SCANDINAVIAN JOURNAL OF RESPIRATORY DISEASES 54: 272 (1973). / SCANDINAVIAN JOURNAL OF RESPIRATORY DISEASES (1973)
CHURCHILL, E.D., THE SEGMENTAL AND LOBULAR PHYSIOLOGY AND PATHOLOGY OF THE LUNG, JOURNAL OF THORACIC SURGERY 18: 279 (1949). (10.1016/S0096-5588(20)31455-0) / JOURNAL OF THORACIC SURGERY (1949)
COCKAYNE, E.A., The genetics of transposition of the viscera, QUARTERLY JOURNAL OF MEDICINE 7: 479 (1938). / QUARTERLY JOURNAL OF MEDICINE (1938)
DALHAMN, T, CILIARY BEAT RATES IN SINUS AND BRONCHIAL MUCOSA FROM BRONCHIECTATIC PERSONS, ARCHIVES OF OTOLARYNGOLOGY 70: 25 (1959). (10.1001/archotol.1959.00730040029004) / ARCHIVES OF OTOLARYNGOLOGY (1959)
DISANTAGNESE, P.A., PATHOGENESIS AND PHYSIOPATHOLOGY OF CYSTIC FIBROSIS OF PANCREAS - FIBROCYSTIC DISEASE OF PANCREAS (MUCOVISCIDOSIS), NEW ENGLAND JOURNAL OF MEDICINE 277: 1399 (1967). (10.1056/NEJM196712282772605) / NEW ENGLAND JOURNAL OF MEDICINE (1967)
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Gibbons, I. R., The Functional Anatomy of the Spermatozoon: 127 (1975). / The Functional Anatomy of the Spermatozoon (1975)
GORHAM, G.W., KARTAGENER TRIAD - A FAMILY STUDY, BULLETIN OF THE JOHNS HOPKINS HOSPITAL 104: 11 (1959). / BULLETIN OF THE JOHNS HOPKINS HOSPITAL (1959)
GUGGENHEIM, F, ISRAEL JOURNAL OF MEDICAL SCIENCES 7: 1079 (1971). / ISRAEL JOURNAL OF MEDICAL SCIENCES (1971)
HOLMES, L.B., A REAPPRAISAL OF KARTAGENERS SYNDROME, AMERICAN JOURNAL OF THE MEDICAL SCIENCES 255: 13 (1968). / AMERICAN JOURNAL OF THE MEDICAL SCIENCES (1968)
KARTAGENER, M, BRONCHIECTASIS WITH SITUS INVERSUS, ARCHIVES OF PEDIATRICS 79: 193 (1962). / ARCHIVES OF PEDIATRICS (1962)
KARTAGENER, M, BEITRAGE ZUR KLINIK DER TUBERKULOSE UND SPEZIFISCHEN TUBERKULOSE-FORSCHUNG 83: 489 (1933). (10.1007/BF02141468) / BEITRAGE ZUR KLINIK DER TUBERKULOSE UND SPEZIFISCHEN TUBERKULOSE-FORSCHUNG (1933)
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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 11:51 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:44 p.m.)
Indexed	1 day, 20 hours ago (Sept. 4, 2025, 9:22 a.m.)
Issued	49 years, 1 month ago (July 23, 1976)
Published	49 years, 1 month ago (July 23, 1976)
Published Print	49 years, 1 month ago (July 23, 1976)

Funders 0

None

BibTeX

@article{Afzelius_1976, title={A Human Syndrome Caused by Immotile Cilia}, volume={193}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1084576}, DOI={10.1126/science.1084576}, number={4250}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Afzelius, Björn A.}, year={1976}, month=jul, pages={317–319} }

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