DOI: 10.1126/science.1082602. Informatics and Quantitative Analysis in Biological Imaging

Informatics and Quantitative Analysis in Biological Imaging

10.1126/science.1082602

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Biological imaging is now a quantitative technique for probing cellular structure and dynamics and is increasingly used for cell-based screens. However, the bioinformatics tools required for hypothesis-driven analysis of digital images are still immature. We are developing the Open Microscopy Environment (OME) as an informatics solution for the storage and analysis of optical microscope image data. OME aims to automate image analysis, modeling, and mining of large sets of images and specifies a flexible data model, a relational database, and an XML-encoded file standard that is usable by potentially any software tool. With this design, OME provides a first step toward biological image informatics.

Bibliography

Swedlow, J. R., Goldberg, I., Brauner, E., & Sorger, P. K. (2003). Informatics and Quantitative Analysis in Biological Imaging. Science, 300(5616), 100â102.

Authors 4

Jason R. Swedlow (first)
Ilya Goldberg (additional)
Erik Brauner (additional)
Peter K. Sorger (additional)

References 15 Referenced 218

10.1016/S0960-9822(02)01139-9
10.1126/science.286.5441.971
10.1038/35042526
10.1109/ISBI.2002.1029259
See www.openmicroscopy.org.
H. Chen J. W. Sedat D. A. Agard in Handbook of Biological Confocal Microscopy J. B. Pawley Ed. (Plenum New York 1989) pp. 141–150. (10.1007/978-1-4615-7133-9_13)
10.1034/j.1600-0854.2002.30105.x
Brazma A., et al., Adv. Biochem. Eng. Biotechnol. 77, 113 (2002). / Adv. Biochem. Eng. Biotechnol. by Brazma A. (2002)
See www.openmicroscopy.org/participants2.htm.
See www.openmicroscopy.org/technology6.htm.
10.1038/ncb809
See www.openmicroscopy.org/OMEV1/OME_V1.html.
10.1016/S0962-8924(00)01880-8
R. N. Bracewell The Fourier Transform and Its Applications (McGraw-Hill New York 1986).
We gratefully acknowledge helpful discussions with our academic and commercial partners (9); G. Danuser; and members of the Swedlow Goldberg and Sorger groups. Research in the authors' laboratories is supported by grants from the Wellcome Trust and Cancer Research UK (J.R.S.) and NIH and the Harvard Institute of Chemistry and Cell Biology (P.K.S and I.G.). J.R.S. is a Wellcome Trust Senior Research Fellow.

Dates

Type	When
Created	22 years, 4 months ago (April 4, 2003, 12:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:15 p.m.)
Indexed	1 month, 3 weeks ago (June 27, 2025, 5:50 a.m.)
Issued	22 years, 4 months ago (April 4, 2003)
Published	22 years, 4 months ago (April 4, 2003)
Published Print	22 years, 4 months ago (April 4, 2003)

Funders 0

None

BibTeX

@article{Swedlow_2003, title={Informatics and Quantitative Analysis in Biological Imaging}, volume={300}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1082602}, DOI={10.1126/science.1082602}, number={5616}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Swedlow, Jason R. and Goldberg, Ilya and Brauner, Erik and Sorger, Peter K.}, year={2003}, month=apr, pages={100–102} }

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