DOI: 10.1126/science.1078231. Toll Pathway-Dependent Blockade of CD4 <sup>+</sup> CD25 <sup>+</sup> T Cell-Mediated Suppression by Dendritic Cells

Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells

10.1126/science.1078231

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Toll-like receptors (TLRs) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (T R cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs, which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4 + CD25 + T R cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.

Bibliography

Pasare, C., & Medzhitov, R. (2003). Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells. Science, 299(5609), 1033â1036.

Authors 2

Chandrashekhar Pasare (first)
Ruslan Medzhitov (additional)

References 30 Referenced 1,582

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We thank A. Rudensky G. Barton E. Kopp and A. Unnifor helpful discussions; S. Akira for the gift of MyD88 TLR2 and TLR4 knockout mice; and G. Dranoff for the gift of Flt3 ligand–expressing cells. This research was supported by the Howard Hughes Medical Institute grants from NIH and a Searle Scholarship to R.M.

Dates

Type	When
Created	22 years, 6 months ago (Feb. 13, 2003, 5:06 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:28 p.m.)
Indexed	4 days, 5 hours ago (Aug. 23, 2025, 9:52 p.m.)
Issued	22 years, 6 months ago (Feb. 14, 2003)
Published	22 years, 6 months ago (Feb. 14, 2003)
Published Print	22 years, 6 months ago (Feb. 14, 2003)

Funders 0

None

BibTeX

@article{Pasare_2003, title={Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells}, volume={299}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1078231}, DOI={10.1126/science.1078231}, number={5609}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pasare, Chandrashekhar and Medzhitov, Ruslan}, year={2003}, month=feb, pages={1033–1036} }

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