DOI: 10.1126/science.1074868. Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles

Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles

10.1126/science.1074868

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

We present an approach to fabricate solid capsules with precise control of size, permeability, mechanical strength, and compatibility. The capsules are fabricated by the self-assembly of colloidal particles onto the interface of emulsion droplets. After the particles are locked together to form elastic shells, the emulsion droplets are transferred to a fresh continuous-phase fluid that is the same as that inside the droplets. The resultant structures, which we call “colloidosomes,” are hollow, elastic shells whose permeability and elasticity can be precisely controlled. The generality and robustness of these structures and their potential for cellular immunoisolation are demonstrated by the use of a variety of solvents, particles, and contents.

Bibliography

Dinsmore, A. D., Hsu, M. F., Nikolaides, M. G., Marquez, M., Bausch, A. R., & Weitz, D. A. (2002). Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles. Science, 298(5595), 1006â1009.

Authors 6

A. D. Dinsmore (first)
Ming F. Hsu (additional)
M. G. Nikolaides (additional)
Manuel Marquez (additional)
A. R. Bausch (additional)
D. A. Weitz (additional)

References 40 Referenced 1,931

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We gratefully acknowledge valuable conversations with V. Gordon D. Nelson and A. Akashe. We also thank A. Schofield for the PMMA particles. We also gratefully acknowledge support from Kraft. This work was also supported by the NSF (DMR-9971432) the Harvard Materials Research Science and Engineering Center (DMR-9809363) and NASA (NAG3-2284). A.B. acknowledges support from the Emmy Noether–Programme of the DFG.

Dates

Type	When
Created	22 years, 10 months ago (Oct. 31, 2002, 5:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:45 p.m.)
Indexed	2 days, 2 hours ago (Sept. 3, 2025, 6:43 a.m.)
Issued	22 years, 10 months ago (Nov. 1, 2002)
Published	22 years, 10 months ago (Nov. 1, 2002)
Published Print	22 years, 10 months ago (Nov. 1, 2002)

Funders 0

None

BibTeX

@article{Dinsmore_2002, title={Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles}, volume={298}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1074868}, DOI={10.1126/science.1074868}, number={5595}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Dinsmore, A. D. and Hsu, Ming F. and Nikolaides, M. G. and Marquez, Manuel and Bausch, A. R. and Weitz, D. A.}, year={2002}, month=nov, pages={1006–1009} }

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