DOI: 10.1126/science.1073031. Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor

Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor

10.1126/science.1073031

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)–anchored protein, whereas the MAG receptor has remained elusive. Here, we show that MAG binds directly, with high affinity, to NgR. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons are rendered MAG-sensitive by expression of NgR. MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury.

Bibliography

Liu, B. P., Fournier, A., GrandPreÌ, T., & Strittmatter, S. M. (2002). Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor. Science, 297(5584), 1190â1193.

Authors 4

Betty P. Liu (first)
Alyson Fournier (additional)
Tadzia GrandPré (additional)
Stephen M. Strittmatter (additional)

References 23 Referenced 458

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J. E. Kim S. Li T. GrandPre D. Qiu S. M. Strittmatter unpublished data.
Supported by research grants from the NIH the McKnight Foundation the Institute for the Study of Aging and Biogen Inc. (S.M.S.); and an institutional training grant from the NIH (B.P.L.). T.G. is a Bayer predoctoral scholar and S.M.S. is an investigator of the Patrick and Catherine Weldon Donaghue Medical Research Foundation.

Dates

Type	When
Created	22 years, 10 months ago (Oct. 1, 2002, 3:34 p.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 9:59 p.m.)
Indexed	1 week, 3 days ago (Aug. 21, 2025, 2:17 p.m.)
Issued	23 years ago (Aug. 16, 2002)
Published	23 years ago (Aug. 16, 2002)
Published Print	23 years ago (Aug. 16, 2002)

Funders 0

None

BibTeX

@article{Liu_2002, title={Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor}, volume={297}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1073031}, DOI={10.1126/science.1073031}, number={5584}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Liu, Betty P. and Fournier, Alyson and GrandPré, Tadzia and Strittmatter, Stephen M.}, year={2002}, month=aug, pages={1190–1193} }

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