DOI: 10.1126/science.1071924. TNF-R1 Signaling: A Beautiful Pathway

10.1126/science.1071924

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor–1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling complex at the cell membrane. Over the past decade, many of the components and mechanisms of these signaling pathways have been elucidated. We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process.

Bibliography

Chen, G., & Goeddel, D. V. (2002). TNF-R1 Signaling: A Beautiful Pathway. Science, 296(5573), 1634â1635.

Authors 2

Guoqing Chen (first)
David V. Goeddel (additional)

References 4 Referenced 1,488

G. Chen D. V. Goeddel TNF Pathway Science's STKE (Connections Map as seen May 2002) .
10.1016/S0092-8674(01)00237-9
10.1146/annurev.immunol.19.1.163
10.1016/S0092-8674(02)00703-1

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 5:54 a.m.)
Deposited	1 year, 7 months ago (Jan. 9, 2024, 11:04 p.m.)
Indexed	15 minutes ago (Sept. 4, 2025, 1:13 a.m.)
Issued	23 years, 3 months ago (May 31, 2002)
Published	23 years, 3 months ago (May 31, 2002)
Published Print	23 years, 3 months ago (May 31, 2002)

Funders 0

None

BibTeX

@article{Chen_2002, title={TNF-R1 Signaling: A Beautiful Pathway}, volume={296}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1071924}, DOI={10.1126/science.1071924}, number={5573}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Chen, Guoqing and Goeddel, David V.}, year={2002}, month=may, pages={1634–1635} }

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